C-reactive protein and outcome after ischemic stroke.


Journal Article

BACKGROUND AND PURPOSE:Elevated concentrations of the acute-phase reactant C-reactive protein (CRP) predict ischemic cardiac events in both hospital- and population-based studies and may signify a role for inflammation in the destabilization of cardiovascular disease. We examined the relationship between CRP and outcome after acute ischemic stroke. METHODS:This was a subgroup analysis from a prospective observational study based in a University Hospital Acute Stroke Unit serving a population of approximately 260 000. Survival time and cause of death for up to 4 years after the index stroke were determined and related to CRP concentration within 72 hours of stroke and known prognostic variables by a Cox proportional hazards regression model. RESULTS:Ischemic stroke was diagnosed in 228 of 283 consecutive admissions. Median follow-up was 959 days. Geometric mean CRP concentration was 10.1 mg/L. Survival in those with CRP >10.1 mg/L was significantly worse than in those with CRP 10.1 mg/L and 63% of deaths in those with CRP

Full Text

Cited Authors

  • Muir, KW; Weir, CJ; Alwan, W; Squire, IB; Lees, KR

Published Date

  • May 1999

Published In

Volume / Issue

  • 30 / 5

Start / End Page

  • 981 - 985

PubMed ID

  • 10229731

Pubmed Central ID

  • 10229731

Electronic International Standard Serial Number (EISSN)

  • 1524-4628

International Standard Serial Number (ISSN)

  • 0039-2499

Digital Object Identifier (DOI)

  • 10.1161/01.str.30.5.981


  • eng