Apolipoprotein E genotype, coagulation, and survival following acute stroke.


Journal Article

The authors hypothesized that divergent influences of the APOE epsilon4 allele on ischemic and hemorrhagic stroke survival might result from differences in coagulation profiles. In 49 hemorrhagic stroke patients, epsilon4 carriers had higher partial thromboplastin time ratios (p < 0.01) than non-epsilon4 carriers. Among 529 ischemic stroke patients, increasing epsilon4 allele dose was associated with improved survival (p = 0.03) after adjusting for baseline NIH stroke scale (p = 0.00001) and partial thromboplastin time ratio (p = 0.01). Relative anticoagulation does not fully explain the survival advantage in epsilon4-carrying ischemic stroke patients.

Full Text

Cited Authors

  • Weir, CJ; McCarron, MO; Muir, KW; Dyker, AG; Bone, I; Lees, KR; Nicoll, JA

Published Date

  • September 2001

Published In

Volume / Issue

  • 57 / 6

Start / End Page

  • 1097 - 1100

PubMed ID

  • 11571342

Pubmed Central ID

  • 11571342

Electronic International Standard Serial Number (EISSN)

  • 1526-632X

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.57.6.1097


  • eng