Early and long-term outcomes of heart failure in elderly persons, 2001-2005.


Journal Article

BACKGROUND: The treatment of chronic heart failure has improved during the past 2 decades, but little is known about whether the improvements are reflected in trends in early and long-term mortality and hospital readmission. METHODS: In a retrospective cohort study of 2 540 838 elderly Medicare beneficiaries hospitalized with heart failure between January 1, 2001, and December 31, 2005, we examined early and long-term all-cause mortality and hospital readmission and patient- and hospital-level predictors of these outcomes. RESULTS: Unadjusted in-hospital mortality declined from 5.1% to 4.2% during the study (P < .001), but 30-day, 180-day, and 1-year all-cause mortality remained fairly constant at 11%, 26%, and 37%, respectively. Nearly 1 in 4 patients were readmitted within 30 days of the index hospitalization, and two-thirds were readmitted within 1 year. Controlling for patient- and hospital-level covariates, the hazard of all-cause mortality at 1 year was slightly lower in 2005 than in 2001 (hazard ratio, 0.98; 95% confidence interval, 0.97-0.99). The hazard of readmission did not decline significantly from 2001 to 2005 (hazard ratio, 0.99; 95% confidence interval, 0.98-1.00). CONCLUSIONS: Early and long-term all-cause mortality and hospital readmission rates remain high and have improved little with time. The need to identify optimal management strategies for these clinically complex patients is urgent.

Full Text

Duke Authors

Cited Authors

  • Curtis, LH; Greiner, MA; Hammill, BG; Kramer, JM; Whellan, DJ; Schulman, KA; Hernandez, AF

Published Date

  • December 8, 2008

Published In

Volume / Issue

  • 168 / 22

Start / End Page

  • 2481 - 2488

PubMed ID

  • 19064833

Pubmed Central ID

  • 19064833

Electronic International Standard Serial Number (EISSN)

  • 1538-3679

Digital Object Identifier (DOI)

  • 10.1001/archinte.168.22.2481


  • eng

Conference Location

  • United States