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Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses.

Publication ,  Journal Article
Nakano, H; Lin, KL; Yanagita, M; Charbonneau, C; Cook, DN; Kakiuchi, T; Gunn, MD
Published in: Nat Immunol
April 2009

T helper type 1 (T(H)1)-polarized immune responses, which confer protection against intracellular pathogens, are thought to be initiated by dendritic cells (DCs) that enter lymph nodes from peripheral tissues. Here we found after viral infection or immunization, inflammatory monocytes were recruited into lymph nodes directly from the blood to become CD11c(+)CD11b(hi)Gr-1(+) inflammatory DCs, which produced abundant interleukin 12p70 and potently stimulated T(H)1 responses. This monocyte extravasation required the chemokine receptor CCR2 but not the chemokine CCL2 or receptor CCR7. Thus, the accumulation of inflammatory DCs and T(H)1 responses were much lower in Ccr2(-/-) mice, were preserved in Ccl2(-/-) mice and were relatively higher in CCL19-CCL21-Ser-deficient plt mutant mice, in which all other lymph node DC types were fewer in number. We conclude that blood-derived inflammatory DCs are important in the development of T(H)1 immune responses.

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Published In

Nat Immunol

DOI

EISSN

1529-2916

Publication Date

April 2009

Volume

10

Issue

4

Start / End Page

394 / 402

Location

United States

Related Subject Headings

  • T-Lymphocytes, Helper-Inducer
  • Receptors, Chemokine
  • Receptors, CCR2
  • Orthomyxoviridae Infections
  • Mice, Mutant Strains
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice, Inbred C3H
  • Mice, Inbred BALB C
  • Mice
 

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Nakano, H., Lin, K. L., Yanagita, M., Charbonneau, C., Cook, D. N., Kakiuchi, T., & Gunn, M. D. (2009). Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. Nat Immunol, 10(4), 394–402. https://doi.org/10.1038/ni.1707
Nakano, Hideki, Kaifeng Lisa Lin, Manabu Yanagita, Chantal Charbonneau, Donald N. Cook, Terutaka Kakiuchi, and Michael D. Gunn. “Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses.Nat Immunol 10, no. 4 (April 2009): 394–402. https://doi.org/10.1038/ni.1707.
Nakano H, Lin KL, Yanagita M, Charbonneau C, Cook DN, Kakiuchi T, et al. Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. Nat Immunol. 2009 Apr;10(4):394–402.
Nakano, Hideki, et al. “Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses.Nat Immunol, vol. 10, no. 4, Apr. 2009, pp. 394–402. Pubmed, doi:10.1038/ni.1707.
Nakano H, Lin KL, Yanagita M, Charbonneau C, Cook DN, Kakiuchi T, Gunn MD. Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. Nat Immunol. 2009 Apr;10(4):394–402.

Published In

Nat Immunol

DOI

EISSN

1529-2916

Publication Date

April 2009

Volume

10

Issue

4

Start / End Page

394 / 402

Location

United States

Related Subject Headings

  • T-Lymphocytes, Helper-Inducer
  • Receptors, Chemokine
  • Receptors, CCR2
  • Orthomyxoviridae Infections
  • Mice, Mutant Strains
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice, Inbred C3H
  • Mice, Inbred BALB C
  • Mice