Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses.

Published

Journal Article

T helper type 1 (T(H)1)-polarized immune responses, which confer protection against intracellular pathogens, are thought to be initiated by dendritic cells (DCs) that enter lymph nodes from peripheral tissues. Here we found after viral infection or immunization, inflammatory monocytes were recruited into lymph nodes directly from the blood to become CD11c(+)CD11b(hi)Gr-1(+) inflammatory DCs, which produced abundant interleukin 12p70 and potently stimulated T(H)1 responses. This monocyte extravasation required the chemokine receptor CCR2 but not the chemokine CCL2 or receptor CCR7. Thus, the accumulation of inflammatory DCs and T(H)1 responses were much lower in Ccr2(-/-) mice, were preserved in Ccl2(-/-) mice and were relatively higher in CCL19-CCL21-Ser-deficient plt mutant mice, in which all other lymph node DC types were fewer in number. We conclude that blood-derived inflammatory DCs are important in the development of T(H)1 immune responses.

Full Text

Duke Authors

Cited Authors

  • Nakano, H; Lin, KL; Yanagita, M; Charbonneau, C; Cook, DN; Kakiuchi, T; Gunn, MD

Published Date

  • April 2009

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 394 - 402

PubMed ID

  • 19252492

Pubmed Central ID

  • 19252492

Electronic International Standard Serial Number (EISSN)

  • 1529-2916

Digital Object Identifier (DOI)

  • 10.1038/ni.1707

Language

  • eng

Conference Location

  • United States