Intraleucocytic malaria pigment and clinical severity of malaria in children.

Journal Article (Journal Article)

Intraleucocytic malaria pigment has been suggested as a measure of disease severity in malaria. We have tested this hypothesis by studying 146 children aged 6 months to 14 years in 4 categories--cerebral malaria, mild malaria, asymptomatic malaria and 'no malaria'--in Ibadan, Nigeria, an area of intense malaria transmission in Africa. Children with cerebral malaria were studied at the university hospital, those with mild malaria at 2 primary health centres and the other 2 groups were studied in a primary school. The proportion of pigment-containing neutrophils showed a clear rise across the spectrum no malaria--asymptomatic malaria--mild malaria--cerebral malaria (median values 2.0%, 6.5%, 9.0% and 27.0%, respectively; P < 0.0001). The proportion of pigment-containing monocytes did not differ significantly between the mild malaria, asymptomatic malaria and no malaria groups but the cerebral malaria group had a higher median value than the other 3 groups. The ratio of pigment-containing neutrophils to pigment-containing monocytes showed the same trend across the groups of subjects as was observed with the number of pigment-containing neutrophils. It is concluded that the pigment-containing neutrophil count is a simple marker of disease severity in childhood malaria in addition to the parasite count.

Full Text

Duke Authors

Cited Authors

  • Amodu, OK; Adeyemo, AA; Olumese, PE; Gbadegesin, RA

Published Date

  • January 1, 1998

Published In

Volume / Issue

  • 92 / 1

Start / End Page

  • 54 - 56

PubMed ID

  • 9692152

International Standard Serial Number (ISSN)

  • 0035-9203

Digital Object Identifier (DOI)

  • 10.1016/s0035-9203(98)90952-x


  • eng

Conference Location

  • England