Bakery flour dust exposure causes non-allergic inflammation and enhances allergic airway inflammation in mice.

Published

Journal Article

Baker's asthma is one of the most commonly reported occupational lung diseases in countries where fresh bread is baked daily in large quantities, and is characterized by rhinitis, bronchial hyperresponsiveness, and reversible airflow obstruction. Epidemiological studies have identified pre-existing atopy as an important risk factor for developing baker's asthma, yet the aetiology and pathogenesis of baker's asthma remain poorly understood.We sought to develop a mouse model of baker's asthma that could be used to characterize the development and progression of baker's asthma.We were unable to sensitize mice to bakery flour dust or flour dust extract. We assessed total inflammatory cells, cellular differential, total serum IgE and the pro-inflammatory cytokine response to oropharyngeally instilled bakery flour dust or flour dust extract by itself or in the context of ovalbumin (OVA) sensitization and challenge.Both bakery flour dust and flour dust extract consistently elicited a neutrophilic inflammation in a Toll-like receptor 4-independent manner; suggesting that endotoxin is not playing a role in the inflammatory response to flour dust. Moreover, bakery flour dust and dust extract significantly enhance the inflammatory response in OVA-sensitized and challenged mice.Bakery flour dust and flour dust extract are strongly pro-inflammatory and can cause non-allergic airway inflammation and can enhance allergen-mediated airway inflammation.

Full Text

Cited Authors

  • Marraccini, P; Brass, DM; Hollingsworth, JW; Maruoka, S; Garantziotis, S; Schwartz, DA

Published Date

  • September 2008

Published In

Volume / Issue

  • 38 / 9

Start / End Page

  • 1526 - 1535

PubMed ID

  • 18564331

Pubmed Central ID

  • 18564331

Electronic International Standard Serial Number (EISSN)

  • 1365-2222

International Standard Serial Number (ISSN)

  • 0954-7894

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2222.2008.03038.x

Language

  • eng