Skip to main content

The effect of calcium antagonists on hypoxic pulmonary hypertension in the piglet.

Publication ,  Journal Article
Dickstein, PJ; Trindade, O; Goldberg, RN; Bancalari, E
Published in: Pediatr Res
December 1984

Cardiovascular responses to the calcium antagonists verapamil and nifedipine were evaluated in a piglet model of hypoxic pulmonary hypertension. All animals were mechanically ventilated and paralyzed. Cardiac output (CO), pulmonary artery (Ppa) and aortic blood pressure (AoP), pulmonary wedge pressure, right atrial pressure (Pra), and arterial blood gases were measured prior to and after pulmonary hypertension was induced by hypoxia and after administration of calcium-blocking agents. Results were compared to a control group of piglets subjected to a similar period of hypoxia. Verapamil infusion (0.15 mg/kg) resulted in a rapid decrease in Ppa, AoP and pulmonary vascular resistance (p less than 0.05) which returned to baseline values by 15 min. Nifedipine (100 micrograms/kg) resulted in a decrease in Ppa at 1 min (p less than 0.05) which remained significantly lower than controls throughout the study period. AoP declined precipitously during the same time period (p less than 0.01). No significant change in Ppa was noted when nifedipine was administered at a dose of 10 micrograms/kg. For the most part, these drugs have a transient vasodilatory action on pulmonary as well as systemic circulation in this animal model; however, they might in higher doses be associated with significant systemic hypotension. For this reason, the use of these drugs in the treatment of hypoxic pulmonary hypertension in the neonate should be approached with caution.

Duke Scholars

Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

December 1984

Volume

18

Issue

12

Start / End Page

1262 / 1265

Location

United States

Related Subject Headings

  • Verapamil
  • Swine
  • Pulmonary Wedge Pressure
  • Pediatrics
  • Nifedipine
  • Hypoxia
  • Hypertension, Pulmonary
  • Cardiac Output
  • Animals, Newborn
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dickstein, P. J., Trindade, O., Goldberg, R. N., & Bancalari, E. (1984). The effect of calcium antagonists on hypoxic pulmonary hypertension in the piglet. Pediatr Res, 18(12), 1262–1265. https://doi.org/10.1203/00006450-198412000-00007
Dickstein, P. J., O. Trindade, R. N. Goldberg, and E. Bancalari. “The effect of calcium antagonists on hypoxic pulmonary hypertension in the piglet.Pediatr Res 18, no. 12 (December 1984): 1262–65. https://doi.org/10.1203/00006450-198412000-00007.
Dickstein PJ, Trindade O, Goldberg RN, Bancalari E. The effect of calcium antagonists on hypoxic pulmonary hypertension in the piglet. Pediatr Res. 1984 Dec;18(12):1262–5.
Dickstein, P. J., et al. “The effect of calcium antagonists on hypoxic pulmonary hypertension in the piglet.Pediatr Res, vol. 18, no. 12, Dec. 1984, pp. 1262–65. Pubmed, doi:10.1203/00006450-198412000-00007.
Dickstein PJ, Trindade O, Goldberg RN, Bancalari E. The effect of calcium antagonists on hypoxic pulmonary hypertension in the piglet. Pediatr Res. 1984 Dec;18(12):1262–1265.

Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

December 1984

Volume

18

Issue

12

Start / End Page

1262 / 1265

Location

United States

Related Subject Headings

  • Verapamil
  • Swine
  • Pulmonary Wedge Pressure
  • Pediatrics
  • Nifedipine
  • Hypoxia
  • Hypertension, Pulmonary
  • Cardiac Output
  • Animals, Newborn
  • Animals