The pharmacokinetics of bumetanide in the newborn infant.

Published

Journal Article

This study characterizes the pharmacokinetics of bumetanide after an intravenous dose of 0.05 or 0.10 mg/kg to 14 neonates (weight range 820-4,000 g; gestational age 26-40 weeks) during the first week of life. Blood samples and urine were collected for up to 12 h after dosing. Estimated serum clearance was 0.2-1.0 ml/min.kg (range), volume of distribution was 0.22 l/kg (range 0.11-0.32 l/kg), and the harmonic mean half-life was 6-7 h (range of 4-19 h). Nonrenal clearance accounted for 58-97% of the serum clearance with the presence of certain oxidative metabolites of bumetanide in the urine. These findings suggest higher dosing requirements and prolonged intervals as compared to adults. Utilizing these pharmacokinetic data, pharmacodynamic and ototoxicity studies should be conducted to establish a safe and effective neonatal dose.

Full Text

Duke Authors

Cited Authors

  • Lopez-Samblas, AM; Adams, JA; Goldberg, RN; Modi, MW

Published Date

  • 1997

Published In

Volume / Issue

  • 72 / 5

Start / End Page

  • 265 - 272

PubMed ID

  • 9395836

Pubmed Central ID

  • 9395836

International Standard Serial Number (ISSN)

  • 0006-3126

Digital Object Identifier (DOI)

  • 10.1159/000244492

Language

  • eng

Conference Location

  • Switzerland