Hyperammonemia associated with perinatal asphyxia.

Journal Article (Journal Article)

Twelve infants with severe perinatal asphyxia were found to have elevated blood ammonia levels (302 to 960 microgram/100 ml). In the seven survivors, hyperammonemia was associated with CNS irritability, hyperthermia, hypertension, and wide neonatal heart rate oscillations. Follow-up examinations revealed severe neurologic dysfunction in five of seven infants. CNS depression, hyperthermia, hypertension, and a nonreactive, fixed heart rate characterized the infants that died. These findings suggest a clinical entity secondary to perinatal asphyxia whose signs and symptoms may be related to hyperammonemia.

Full Text

Duke Authors

Cited Authors

  • Goldberg, RN; Cabal, LA; Sinatra, FR; Plajstek, CE; Hodgman, JE

Published Date

  • September 1, 1979

Published In

Volume / Issue

  • 64 / 3

Start / End Page

  • 336 - 341

PubMed ID

  • 481980

International Standard Serial Number (ISSN)

  • 0031-4005


  • eng

Conference Location

  • United States