Single-dose captopril scintigraphy in the neonate with renovascular hypertension: prediction of renal failure, a side effect of captopril therapy.

Journal Article (Journal Article)

Baseline and single-dose captopril scintigraphy with 1 mCi of 99mTc-diethylenetriamine-pentaacetic acid (or 99mTc-glucoheptonate) was performed in 5 neonates with renovascular hypertension. Unilateral renal artery thrombosis and/or renal infarction was associated with severe impairment or lack of function on both studies (3 patients). Renal ischemia due to aortic thrombus manifested itself as lack of function only following captopril (2 patients). This approach predicted renal failure as a side effect of captopril therapy in 2 patients, 1 with unilateral (contralateral kidney infarcted) and the other with bilateral renal ischemia from aortic thrombus. Single-dose captopril scintigraphy may be a useful tool to predict tolerance to captopril therapy.

Full Text

Duke Authors

Cited Authors

  • Sfakianakis, GN; Sfakianaki, E; Paredes, A; Abitbol, C; Zilleruelo, G; Goldberg, RN; Strauss, J

Published Date

  • 1988

Published In

Volume / Issue

  • 54 / 5

Start / End Page

  • 246 - 253

PubMed ID

  • 3060199

International Standard Serial Number (ISSN)

  • 0006-3126

Digital Object Identifier (DOI)

  • 10.1159/000242859


  • eng

Conference Location

  • Switzerland