Dynamic change of fecal calprotectin in very low birth weight infants during the first month of life.

Journal Article (Journal Article)

BACKGROUND: Calprotectin is a cytosolic component of neutrophils. Fecal calprotectin (FC) level is a useful marker for exacerbation of inflammatory bowel disease in children. FC may be a useful marker for necrotizing enterocolitis (NEC). OBJECTIVE: To determine normal baseline levels of FC and observe dynamic changes of FC levels over the first postnatal month in very low birth weight (VLBW) infants. METHODS: FC levels of 14 VLBW infants (gestational age 23-30 weeks, birth weight 350 microg/g stool was noted with signs of gastrointestinal injury, such as bloody stool and bowel perforation. FC levels decreased after initiation of treatments in sick infants who recovered. CONCLUSIONS: FC levels may be a marker for early diagnosis and resolution of gastrointestinal illnesses in VLBW infants. Its utility for early diagnosis and assessment of resolution of NEC should be studied in a larger cohort of VLBW infants.

Full Text

Duke Authors

Cited Authors

  • Yang, Q; Smith, PB; Goldberg, RN; Cotten, CM

Published Date

  • 2008

Published In

Volume / Issue

  • 94 / 4

Start / End Page

  • 267 - 271

PubMed ID

  • 18784422

Pubmed Central ID

  • PMC2790758

Electronic International Standard Serial Number (EISSN)

  • 1661-7819

Digital Object Identifier (DOI)

  • 10.1159/000151645


  • eng

Conference Location

  • Switzerland