Inclusion of a sensitivity control to add a quality-control parameter and improve reproducibility in BCR, immunoglobulin, and T-cell receptor gene-rearrangement studies.

Journal Article (Journal Article)

Molecular analyses to determine clonality of T and B cells in malignant lymphoma and leukemia and to detect the (9;22) translocation in chronic myelogenous leukemia are commonly used in clinical molecular biology laboratories. We describe the inclusion of a sensitivity control in each of these assays derived from DNA of well-characterized cell lines. The inclusion of such a sample adds an important quality-control parameter to ensure assay-to-assay reproducibility and to satisfy accreditation and regulatory requirements.

Full Text

Duke Authors

Cited Authors

  • Devlin, BH; Ratech, H; Kaufman, R

Published Date

  • December 1994

Published In

Volume / Issue

  • 3 / 4

Start / End Page

  • 271 - 274

PubMed ID

  • 7866638

International Standard Serial Number (ISSN)

  • 1052-9551

Digital Object Identifier (DOI)

  • 10.1097/00019606-199412000-00010


  • eng

Conference Location

  • United States