Leptomeningeal dissemination of optic pathway gliomas in three children.

Journal Article (Journal Article)

We treated three children with optic pathway gliomas who had progressive disease associated with metastatic spread to the leptomeninges. One patient had radiographic resolution of leptomeningeal disease after treatment with intravenous carmustine and oral mercaptopurine but died of progressive pulmonary fibrosis. The second patient was treated with intravenous thiotepa, and the leptomeningeal disease remained stable. The third patient was treated with intravenous vincristine sulfate, cyclophosphamide, cisplatin, and etoposide and had a significant size reduction of the leptomeningeal lesion. Although leptomeningeal dissemination is a seemingly rare event, it is important that all children with optic pathway gliomas be considered for this possibility, particularly after the onset of new, atypical neurologic symptoms.

Full Text

Duke Authors

Cited Authors

  • Bruggers, CS; Friedman, HS; Phillips, PC; Wiener, MD; Hockenberger, B; Oakes, WJ; Buckley, EG

Published Date

  • June 15, 1991

Published In

Volume / Issue

  • 111 / 6

Start / End Page

  • 719 - 723

PubMed ID

  • 2039043

International Standard Serial Number (ISSN)

  • 0002-9394

Digital Object Identifier (DOI)

  • 10.1016/s0002-9394(14)76778-9


  • eng

Conference Location

  • United States