Neurologic impairment 10 years after optic neuritis.


Journal Article

BACKGROUND: Participants enrolled in the Optic Neuritis Treatment Trial have been observed for more than a decade to assess the relationship between optic neuritis and the development of clinically definite multiple sclerosis. OBJECTIVE: To assess neurologic disability 10 to 12 years after an initial episode of optic neuritis. DESIGN: Longitudinal follow-up of a clinical trial. SETTING: Fourteen Optic Neuritis Treatment Trial clinical centers performed standardized neurologic examinations, including an assessment of neurologic disability. PARTICIPANTS: One hundred twenty-seven patients who had developed clinically definite multiple sclerosis. MAIN OUTCOME MEASURES: Functional Systems Scale and Expanded Disability Status Scale. RESULTS: The disability of most patients was mild, with 65% of patients having an Expanded Disability Status Scale score lower than 3.0. The degree of disability appeared to be unrelated to whether the baseline magnetic resonance imaging scan was lesion-free or showed lesions (P =.51). Among patients with baseline lesions, the degree of disability was unrelated to the number of lesions that were present on the scan (P =.14). Two patients died owing to severe multiple sclerosis, one of whom had no lesions revealed on the baseline scan. CONCLUSION: Most patients who develop clinically definite multiple sclerosis following an initial episode of optic neuritis will have a relatively benign course for at least 10 years.

Full Text

Duke Authors

Cited Authors

  • Beck, RW; Smith, CH; Gal, RL; Xing, D; Bhatti, MT; Brodsky, MC; Buckley, EG; Chrousos, GA; Corbett, J; Eggenberger, E; Goodwin, JA; Katz, B; Kaufman, DI; Keltner, JL; Kupersmith, MJ; Miller, NR; Moke, PS; Nazarian, S; Orengo-Nania, S; Savino, PJ; Shults, WT; Trobe, JD; Wall, M; Optic Neuritis Study Group,

Published Date

  • September 2004

Published In

Volume / Issue

  • 61 / 9

Start / End Page

  • 1386 - 1389

PubMed ID

  • 15364684

Pubmed Central ID

  • 15364684

International Standard Serial Number (ISSN)

  • 0003-9942

Digital Object Identifier (DOI)

  • 10.1001/archneur.61.9.1386


  • eng

Conference Location

  • United States