Adult-onset primary open angle glaucoma does not localize to chromosome 2cen-q13 in North American families.

Published

Journal Article

Glaucoma is one of the leading causes of irreversible blindness in the world and is characterized by elevated intraocular pressure, optic nerve atrophy, and progressive visual field loss. Primary open angle glaucoma (POAG) is the most common subtype of glaucoma in the United States. Recently, Stoilova and coworkers [Genomics 1996;36:142-150] identified a locus for POAG on chromosome 2 (2cen-q13) in families primarily located in the United Kingdom. We examined families with POAG identified within the US for linkage to the 2cen-q13 locus. A total of 18 families with POAG were used in the analysis. Of 77 family members, 46 were classified as affected and 31 were either glaucoma suspects or considered normal. Eight highly polymorphic and informative markers flanking and distributed throughout the region were used. Parametric lod score analysis was performed using both a dominant and recessive low penetrance or 'affecteds-only' model. Multipoint affected sibpair exclusion mapping was also performed. Lod score (both models) and sibpair analysis excluded linkage of the POAG phenotype to the 2cen-q13 region in these families. These data suggest that the chromosome 2cen-q13 locus does not explain a substantial amount of genetic variation in familial POAG.

Full Text

Duke Authors

Cited Authors

  • Allingham, RR; Wiggs, JL; Damji, KF; Herndon, L; Youn, J; Tallett, DA; Jones, KH; Del Bono, EA; Reardon, M; Haines, JL; Pericak-Vance, MA

Published Date

  • September 1998

Published In

Volume / Issue

  • 48 / 5

Start / End Page

  • 251 - 255

PubMed ID

  • 9748694

Pubmed Central ID

  • 9748694

International Standard Serial Number (ISSN)

  • 0001-5652

Digital Object Identifier (DOI)

  • 10.1159/000022812

Language

  • eng

Conference Location

  • Switzerland