The importance of initial management in the treatment of severe infectious corneal ulcers.

Journal Article (Journal Article)

PURPOSE: To identify factors that influence the outcome of patients with severe infectious corneal ulcers. METHOD: A retrospective review was performed of the hospital records of all such patients admitted to the Doheny Eye Hospital during a 30 month period. Outcome variables examined were change in visual acuity, duration of hospitalization, hospital charges, and percentage of patients who required penetrating keratoplasty. RESULTS: Sixty-two ulcers were included. An organism was identified and antibiotic sensitivities established in 52 patients (84%). Inpatient therapy involved a combination of fortified aminoglycoside and cephalosporin antibiotics in 39 patients (63%) and was found to be appropriate on the basis of sensitivity studies in 49 (94%) of 52 patients. Inappropriate initial treatment was related to increased hospital charge (P = 0.024) as well as increased risk of penetrating keratoplasty (P = 0.001). CONCLUSIONS: Appropriate initial therapy is most critical in the course of serious corneal ulcers, and aggressive, broad-spectrum antibiotic coverage is advocated.

Full Text

Duke Authors

Cited Authors

  • McLeod, SD; LaBree, LD; Tayyanipour, R; Flowers, CW; Lee, PP; McDonnell, PJ

Published Date

  • December 1995

Published In

Volume / Issue

  • 102 / 12

Start / End Page

  • 1943 - 1948

PubMed ID

  • 9098300

International Standard Serial Number (ISSN)

  • 0161-6420

Digital Object Identifier (DOI)

  • 10.1016/s0161-6420(95)30771-3


  • eng

Conference Location

  • United States