The mammalian urine concentrating mechanism: hypotheses and uncertainties.

Journal Article (Review;Journal Article)

The urine concentrating mechanism of the mammalian kidney, which can produce a urine that is substantially more concentrated than blood plasma during periods of water deprivation, is one of the enduring mysteries in traditional physiology. Owing to the complex lateral and axial relationships of tubules and vessels, in both the outer and inner medulla, the urine concentrating mechanism may only be fully understood in terms of the kidney's three-dimensional functional architecture and its implications for preferential interactions among tubules and vessels.

Full Text

Duke Authors

Cited Authors

  • Layton, AT; Layton, HE; Dantzler, WH; Pannabecker, TL

Published Date

  • August 2009

Published In

Volume / Issue

  • 24 /

Start / End Page

  • 250 - 256

PubMed ID

  • 19675356

Electronic International Standard Serial Number (EISSN)

  • 1548-9221

International Standard Serial Number (ISSN)

  • 1548-9213

Digital Object Identifier (DOI)

  • 10.1152/physiol.00013.2009


  • eng