Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm.

Journal Article (Journal Article;Review)

Endogenous formation of nitric oxide (NO) and related nitrogen oxides in the vascular system is critical to regulation of multiple physiological functions. An imbalance in the production or availability of these species can result in progression of disease. Nitrogen oxide research in the cardiovascular system has primarily focused on the effects of NO and higher oxidation products. However, nitroxyl (HNO), the one-electron-reduction product of NO, has recently been shown to have unique and potentially beneficial pharmacological properties. HNO and NO often induce discrete biological responses, providing an interesting redox system. This article discusses the emerging aspects of HNO chemistry and attempts to provide a framework for the distinct effects of NO and HNO in vivo.

Full Text

Duke Authors

Cited Authors

  • Wink, DA; Miranda, KM; Katori, T; Mancardi, D; Thomas, DD; Ridnour, L; Espey, MG; Feelisch, M; Colton, CA; Fukuto, JM; Pagliaro, P; Kass, DA; Paolocci, N

Published Date

  • December 2003

Published In

Volume / Issue

  • 285 / 6

Start / End Page

  • H2264 - H2276

PubMed ID

  • 12855429

International Standard Serial Number (ISSN)

  • 0363-6135

Digital Object Identifier (DOI)

  • 10.1152/ajpheart.00531.2003


  • eng

Conference Location

  • United States