Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists.

Journal Article (Journal Article)

The effectiveness of several excitatory amino acid antagonists to delay or block seizures induced by oxygen at high pressure was examined in mice. Of the antagonists tested, namely, L-proline, DL-alpha-aminoadipate, DL-2-amino-5-phosphonovalerate, and L-glutamic acid diethyl ester, DL-2-amino-5-phosphonovalerate was the most effective in delaying or preventing seizures. L-Glutamic acid diethylester was also effective but at significantly higher doses, which were also associated with marked sedation.

Full Text

Duke Authors

Cited Authors

  • Colton, CA; Colton, JS

Published Date

  • May 1, 1985

Published In

Volume / Issue

  • 63 / 5

Start / End Page

  • 519 - 521

PubMed ID

  • 2864124

International Standard Serial Number (ISSN)

  • 0008-4212

Digital Object Identifier (DOI)

  • 10.1139/y85-090


  • eng

Conference Location

  • Canada