Skip to main content
Journal cover image

Compartmentalized nitrosation and nitration in mitochondria.

Publication ,  Journal Article
Ghafourifar, P; Colton, CA
Published in: Antioxid Redox Signal
June 2003

A wide spectrum of the biological actions of nitric oxide and its oxidizing metabolites are mediated via mitochondria. Mitochondria are highly compartmentalized organelles consisting of three distinct compartments: the matrix, the intermembrane space, and the membranes. These compartments are different in their electrochemical properties, redox state, pH, enzymes, and ion content. Nitric oxide and its reactive species react within these compartments in distinct manners. The mitochondrial intermembrane space provides an environment that favors S-nitrosation, whereas nitration occurs largely within the matrix. This article will review some of the interactions of these species with certain mitochondrial respiratory chain complexes, apoptotic proteins, and enzymes. The reversibility and the suborganelle preference of these reactions will be discussed.

Duke Scholars

Published In

Antioxid Redox Signal

DOI

ISSN

1523-0864

Publication Date

June 2003

Volume

5

Issue

3

Start / End Page

349 / 354

Location

United States

Related Subject Headings

  • Sulfhydryl Compounds
  • Reactive Nitrogen Species
  • Oxidation-Reduction
  • Nitrosation
  • Nitric Oxide
  • Mitochondria
  • Humans
  • Hemeproteins
  • Electron Transport
  • Cell Compartmentation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ghafourifar, P., & Colton, C. A. (2003). Compartmentalized nitrosation and nitration in mitochondria. Antioxid Redox Signal, 5(3), 349–354. https://doi.org/10.1089/152308603322110913
Ghafourifar, Pedram, and Carol A. Colton. “Compartmentalized nitrosation and nitration in mitochondria.Antioxid Redox Signal 5, no. 3 (June 2003): 349–54. https://doi.org/10.1089/152308603322110913.
Ghafourifar P, Colton CA. Compartmentalized nitrosation and nitration in mitochondria. Antioxid Redox Signal. 2003 Jun;5(3):349–54.
Ghafourifar, Pedram, and Carol A. Colton. “Compartmentalized nitrosation and nitration in mitochondria.Antioxid Redox Signal, vol. 5, no. 3, June 2003, pp. 349–54. Pubmed, doi:10.1089/152308603322110913.
Ghafourifar P, Colton CA. Compartmentalized nitrosation and nitration in mitochondria. Antioxid Redox Signal. 2003 Jun;5(3):349–354.
Journal cover image

Published In

Antioxid Redox Signal

DOI

ISSN

1523-0864

Publication Date

June 2003

Volume

5

Issue

3

Start / End Page

349 / 354

Location

United States

Related Subject Headings

  • Sulfhydryl Compounds
  • Reactive Nitrogen Species
  • Oxidation-Reduction
  • Nitrosation
  • Nitric Oxide
  • Mitochondria
  • Humans
  • Hemeproteins
  • Electron Transport
  • Cell Compartmentation