Production of superoxide anions by a CNS macrophage, the microglia.
Journal Article (Journal Article)
Microglia have been implicated in both physiological and pathological processes of the brain. Their possible roles have been compared to those of macrophages and granulocytes. Here we demonstrate that specific ability of microglia to secrete the superoxide radical ion in response to a complement activated agent, opsonized zymosan, and to phorbol myristate acetate. As in other organs, this endogenously produced reactive oxygen intermediate could have both beneficial and deleterious effects.
- Colton, CA; Gilbert, DL
- November 2, 1987
Volume / Issue
- 223 / 2
Start / End Page
- 284 - 288
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)