Production of superoxide anions by a CNS macrophage, the microglia.

Journal Article (Journal Article)

Microglia have been implicated in both physiological and pathological processes of the brain. Their possible roles have been compared to those of macrophages and granulocytes. Here we demonstrate that specific ability of microglia to secrete the superoxide radical ion in response to a complement activated agent, opsonized zymosan, and to phorbol myristate acetate. As in other organs, this endogenously produced reactive oxygen intermediate could have both beneficial and deleterious effects.

Full Text

Duke Authors

Cited Authors

  • Colton, CA; Gilbert, DL

Published Date

  • November 2, 1987

Published In

Volume / Issue

  • 223 / 2

Start / End Page

  • 284 - 288

PubMed ID

  • 2822487

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/0014-5793(87)80305-8


  • eng

Conference Location

  • England