Depression of glutamate-mediated synaptic transmission by benzyl alcohol.
Journal Article (Journal Article)
The data obtained from this study suggest that the nonionizable anesthetic benzyl alcohol has two prominent actions on GABA- and glutamate-mediated synaptic transmission at the lobster neuromuscular junction. They are as follows: (1) depression of the excitatory end-plate potential and the postsynaptic membrane response to applied glutamate, and (2) a hyperpolarization of the postsynaptic resting membrane potential associated with a decrease in effective membrane resistance. No change in amplitude of the inhibitory end-plate potential or inhibitory reversal potential was seen. Excitatory miniature end-plate potential frequency was also unaffected. The depression of excitatory synaptic transmission appears to be due to a decreased responsiveness of the postsynaptic receptor-ionophore complex.
- Colton, CA; Colton, JS
- August 1977
Volume / Issue
- 55 / 4
Start / End Page
- 917 - 922
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)