Depression of glutamate-mediated synaptic transmission by benzyl alcohol.

Journal Article

The data obtained from this study suggest that the nonionizable anesthetic benzyl alcohol has two prominent actions on GABA- and glutamate-mediated synaptic transmission at the lobster neuromuscular junction. They are as follows: (1) depression of the excitatory end-plate potential and the postsynaptic membrane response to applied glutamate, and (2) a hyperpolarization of the postsynaptic resting membrane potential associated with a decrease in effective membrane resistance. No change in amplitude of the inhibitory end-plate potential or inhibitory reversal potential was seen. Excitatory miniature end-plate potential frequency was also unaffected. The depression of excitatory synaptic transmission appears to be due to a decreased responsiveness of the postsynaptic receptor-ionophore complex.

Full Text

Duke Authors

Cited Authors

  • Colton, CA; Colton, JS

Published Date

  • August 1, 1977

Published In

Volume / Issue

  • 55 / 4

Start / End Page

  • 917 - 922

PubMed ID

  • 198078

International Standard Serial Number (ISSN)

  • 0008-4212

Language

  • eng

Conference Location

  • Canada