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Depression of glutamate-mediated synaptic transmission by benzyl alcohol.

Publication ,  Journal Article
Colton, CA; Colton, JS
Published in: Can J Physiol Pharmacol
August 1977

The data obtained from this study suggest that the nonionizable anesthetic benzyl alcohol has two prominent actions on GABA- and glutamate-mediated synaptic transmission at the lobster neuromuscular junction. They are as follows: (1) depression of the excitatory end-plate potential and the postsynaptic membrane response to applied glutamate, and (2) a hyperpolarization of the postsynaptic resting membrane potential associated with a decrease in effective membrane resistance. No change in amplitude of the inhibitory end-plate potential or inhibitory reversal potential was seen. Excitatory miniature end-plate potential frequency was also unaffected. The depression of excitatory synaptic transmission appears to be due to a decreased responsiveness of the postsynaptic receptor-ionophore complex.

Duke Scholars

Published In

Can J Physiol Pharmacol

DOI

ISSN

0008-4212

Publication Date

August 1977

Volume

55

Issue

4

Start / End Page

917 / 922

Location

Canada

Related Subject Headings

  • Synaptic Transmission
  • Synapses
  • Physiology
  • Neuromuscular Junction
  • Nephropidae
  • Motor Endplate
  • Membrane Potentials
  • In Vitro Techniques
  • Glutamates
  • Depression, Chemical
 

Citation

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Colton, C. A., & Colton, J. S. (1977). Depression of glutamate-mediated synaptic transmission by benzyl alcohol. Can J Physiol Pharmacol, 55(4), 917–922. https://doi.org/10.1139/y77-122
Colton, C. A., and J. S. Colton. “Depression of glutamate-mediated synaptic transmission by benzyl alcohol.Can J Physiol Pharmacol 55, no. 4 (August 1977): 917–22. https://doi.org/10.1139/y77-122.
Colton CA, Colton JS. Depression of glutamate-mediated synaptic transmission by benzyl alcohol. Can J Physiol Pharmacol. 1977 Aug;55(4):917–22.
Colton, C. A., and J. S. Colton. “Depression of glutamate-mediated synaptic transmission by benzyl alcohol.Can J Physiol Pharmacol, vol. 55, no. 4, Aug. 1977, pp. 917–22. Pubmed, doi:10.1139/y77-122.
Colton CA, Colton JS. Depression of glutamate-mediated synaptic transmission by benzyl alcohol. Can J Physiol Pharmacol. 1977 Aug;55(4):917–922.

Published In

Can J Physiol Pharmacol

DOI

ISSN

0008-4212

Publication Date

August 1977

Volume

55

Issue

4

Start / End Page

917 / 922

Location

Canada

Related Subject Headings

  • Synaptic Transmission
  • Synapses
  • Physiology
  • Neuromuscular Junction
  • Nephropidae
  • Motor Endplate
  • Membrane Potentials
  • In Vitro Techniques
  • Glutamates
  • Depression, Chemical