Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation.

Published

Journal Article (Review)

The role of nitric oxide (NO) in cellular physiology and signaling has been an important aspect in biomedical science over the last decade. As NO is a small uncharged radical, the chemistry of NO within the redox environment of the cell dictates the majority of its biological effects. The mechanisms that have received the most attention from a biological perspective involve reactions with oxygen and superoxide, despite the rich literature of metal-NO chemistry. However, NO and its related species participate in important chemistry with metalloproteins. In addition to the well known direct interactions of NO with heme proteins such as soluble guanylate cyclase and oxyhemoglobin, there is much important, but often underappreciated, chemistry between other nitrogen oxides and heme/metal proteins. Here the basic chemistry of nitrosylation and the interactions of NO and other nitrogen oxides with metal-oxo species such as found in peroxidases and monoxygenases are discussed.

Full Text

Duke Authors

Cited Authors

  • Thomas, DD; Miranda, KM; Colton, CA; Citrin, D; Espey, MG; Wink, DA

Published Date

  • June 2003

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 307 - 317

PubMed ID

  • 12880485

Pubmed Central ID

  • 12880485

International Standard Serial Number (ISSN)

  • 1523-0864

Digital Object Identifier (DOI)

  • 10.1089/152308603322110887

Language

  • eng

Conference Location

  • United States