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Quality of life among patients with Stage II and III breast carcinoma randomized to receive high-dose chemotherapy with autologous bone marrow support or intermediate-dose chemotherapy: results from Cancer and Leukemia Group B 9066.

Publication ,  Journal Article
Peppercorn, J; Herndon, J; Kornblith, AB; Peters, W; Ahles, T; Vredenburgh, J; Schwartz, G; Shpall, E; Hurd, DD; Holland, J; Winer, E
Published in: Cancer
October 15, 2005

BACKGROUND: The objective of this study was to compare the quality of life (QOL) after treatment among patients who had breast carcinoma with multiple positive lymph nodes. The patients were randomized to receive either high-dose chemotherapy with autologous stem cell support (HDC) or intermediate-dose chemotherapy (IDC) in the adjuvant setting. METHODS: Two hundred forty-six patients with AJCC Stage IIA, IIB, or IIIA breast carcinoma who had > or = 10 positive lymph nodes and who were participants in Cancer and Leukemia Group B (CALGB) 9082 were enrolled in this companion study, CALGB 9066. Patients were randomized to receive either high-dose cyclophosphamide, carmustine, and cisplatin (CPA/cDDP/BCNU) and autologous bone marrow transplantation (the HDC arm) or intermediate-dose CPA/cDDP/BCNU as consolidation to adjuvant chemotherapy (the IDC arm). QOL was assessed at baseline and at 3 months, 12 months, 24 months, and 36 months using the Functional Living Index-Cancer (FLIC), the Psychosocial Adjustment to Illness Scale (PAIS)-Self Report, and the McCorkle Symptom Distress Scale (SDS). RESULTS: At the 3-month assessment, patients in the HDC arm demonstrated significant worsening of QOL compared with the IDC arm in terms of their physical well being (FLIC, P = 0.023), social functioning (FLIC, P = 0.026; PAIS, P < 0.0001), symptom distress (SDS, P = 0.0002), and total QOL scores (FLIC, P = 0.042). At 12 months, the differences in QOL scores between the HDC arm and the IDC arm had resolved. CONCLUSIONS: Patients who received more intensive adjuvant therapy experienced transient declines in QOL. By 12 months after therapy, QOL was comparable between the 2 arms, regardless of therapy intensity, and many QOL areas were improved from baseline.

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Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

October 15, 2005

Volume

104

Issue

8

Start / End Page

1580 / 1589

Location

United States

Related Subject Headings

  • Transplantation, Autologous
  • Time Factors
  • Survival Rate
  • Quality of Life
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Humans
  • Female
  • Dose-Response Relationship, Drug
 

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Peppercorn, J., Herndon, J., Kornblith, A. B., Peters, W., Ahles, T., Vredenburgh, J., … Winer, E. (2005). Quality of life among patients with Stage II and III breast carcinoma randomized to receive high-dose chemotherapy with autologous bone marrow support or intermediate-dose chemotherapy: results from Cancer and Leukemia Group B 9066. Cancer, 104(8), 1580–1589. https://doi.org/10.1002/cncr.21363
Peppercorn, Jeffrey, James Herndon, Alice B. Kornblith, William Peters, Tim Ahles, James Vredenburgh, Gary Schwartz, et al. “Quality of life among patients with Stage II and III breast carcinoma randomized to receive high-dose chemotherapy with autologous bone marrow support or intermediate-dose chemotherapy: results from Cancer and Leukemia Group B 9066.Cancer 104, no. 8 (October 15, 2005): 1580–89. https://doi.org/10.1002/cncr.21363.
Peppercorn J, Herndon J, Kornblith AB, Peters W, Ahles T, Vredenburgh J, Schwartz G, Shpall E, Hurd DD, Holland J, Winer E. Quality of life among patients with Stage II and III breast carcinoma randomized to receive high-dose chemotherapy with autologous bone marrow support or intermediate-dose chemotherapy: results from Cancer and Leukemia Group B 9066. Cancer. 2005 Oct 15;104(8):1580–1589.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

October 15, 2005

Volume

104

Issue

8

Start / End Page

1580 / 1589

Location

United States

Related Subject Headings

  • Transplantation, Autologous
  • Time Factors
  • Survival Rate
  • Quality of Life
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Humans
  • Female
  • Dose-Response Relationship, Drug