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Alternating irradiation and chemotherapy in stage III A and B nonsmall cell lung cancer: report of a cancer and Leukemia Group B phase II study 8636.

Publication ,  Journal Article
Seagren, SL; Herndon, JE; Baeker, JR; Boles, M; Chung, C; Green, MR
Published in: Int J Radiat Oncol Biol Phys
July 30, 1994

PURPOSE: A pilot trial testing the feasibility of chemotherapy and radiotherapy was done in Stage III A and B nonsmall cell lung cancer. The schedule was designed to be consistent with the laboratory model of Looney and Hopkins. METHODS AND MATERIALS: Treatment began with thrice-per-day radiotherapy for 3 days (16.2 Gy/nine fractions), followed by chemotherapy (cis-platinum 100 mg/m2 day 10, and vinblastine 4 mg/m2 days 10 and 12). A second cycle started on day 22, a third on day 43, and a fourth on day 64. We treated three cohorts. The first cohort received three cycles of radiotherapy alone, (48.6 Gy). The second cohort received three completed cycles, and the third received three completed cycles and a fourth radiotherapy course (64.8 Gy). Patients were evaluated for toxicity, protocol compliance, response, and survival. RESULTS: The patients in the first cohort experienced no toxicity. Fifty-six percent (56%) of the patients treated in cohort 2 experienced severe or life-threatening myelosuppression as did 82% of those in cohort 3. Nonhematologic toxicity was not severe; one case of Grade 3 esophagitis, one of reversible adult respiratory distress syndrome, and one radiation pneumonitis. We closed the trial after accrual to the third cohort because of significant myelosuppression. CONCLUSION: This schedule is too myelosuppressive to be used without modification.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

July 30, 1994

Volume

29

Issue

5

Start / End Page

1085 / 1088

Location

United States

Related Subject Headings

  • Vinblastine
  • Radiotherapy Dosage
  • Pilot Projects
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Female
 

Citation

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Seagren, S. L., Herndon, J. E., Baeker, J. R., Boles, M., Chung, C., & Green, M. R. (1994). Alternating irradiation and chemotherapy in stage III A and B nonsmall cell lung cancer: report of a cancer and Leukemia Group B phase II study 8636. Int J Radiat Oncol Biol Phys, 29(5), 1085–1088. https://doi.org/10.1016/0360-3016(94)90404-9
Seagren, S. L., J. E. Herndon, J. R. Baeker, M. Boles, C. Chung, and M. R. Green. “Alternating irradiation and chemotherapy in stage III A and B nonsmall cell lung cancer: report of a cancer and Leukemia Group B phase II study 8636.Int J Radiat Oncol Biol Phys 29, no. 5 (July 30, 1994): 1085–88. https://doi.org/10.1016/0360-3016(94)90404-9.
Seagren SL, Herndon JE, Baeker JR, Boles M, Chung C, Green MR. Alternating irradiation and chemotherapy in stage III A and B nonsmall cell lung cancer: report of a cancer and Leukemia Group B phase II study 8636. Int J Radiat Oncol Biol Phys. 1994 Jul 30;29(5):1085–8.
Seagren, S. L., et al. “Alternating irradiation and chemotherapy in stage III A and B nonsmall cell lung cancer: report of a cancer and Leukemia Group B phase II study 8636.Int J Radiat Oncol Biol Phys, vol. 29, no. 5, July 1994, pp. 1085–88. Pubmed, doi:10.1016/0360-3016(94)90404-9.
Seagren SL, Herndon JE, Baeker JR, Boles M, Chung C, Green MR. Alternating irradiation and chemotherapy in stage III A and B nonsmall cell lung cancer: report of a cancer and Leukemia Group B phase II study 8636. Int J Radiat Oncol Biol Phys. 1994 Jul 30;29(5):1085–1088.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

July 30, 1994

Volume

29

Issue

5

Start / End Page

1085 / 1088

Location

United States

Related Subject Headings

  • Vinblastine
  • Radiotherapy Dosage
  • Pilot Projects
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Female