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Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas.

Publication ,  Journal Article
Glantz, MJ; Burger, PC; Herndon, JE; Friedman, AH; Cairncross, JG; Vick, NA; Schold, SC
Published in: Neurology
November 1991

Stereotactic biopsy of CNS tumors provides a small amount of tissue for pathologic diagnosis. This potentially leads to inaccurate grading of gliomas because of their histologic heterogeneity. We compared histologic diagnoses in a consecutive series of 329 patients with newly diagnosed anaplastic gliomas whose diagnoses were established by either stereotactic biopsy or open resection. Of 262 patients undergoing resection, 214 (82%) had glioblastomas and 48 (18%) had anaplastic astrocytomas (AAs). Of 67 patients undergoing stereotactic biopsy, 33 (49%) had glioblastomas and 34 (51%) had AAs. This difference suggests that some AAs diagnosed by stereotactic biopsy are actually glioblastomas and has important implications for the design and interpretation of clinical trials.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

November 1991

Volume

41

Issue

11

Start / End Page

1741 / 1744

Location

United States

Related Subject Headings

  • Stereotaxic Techniques
  • Sex Factors
  • Sensitivity and Specificity
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Glioblastoma
  • Functional Laterality
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Glantz, M. J., Burger, P. C., Herndon, J. E., Friedman, A. H., Cairncross, J. G., Vick, N. A., & Schold, S. C. (1991). Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas. Neurology, 41(11), 1741–1744. https://doi.org/10.1212/wnl.41.11.1741
Glantz, M. J., P. C. Burger, J. E. Herndon, A. H. Friedman, J. G. Cairncross, N. A. Vick, and S. C. Schold. “Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas.Neurology 41, no. 11 (November 1991): 1741–44. https://doi.org/10.1212/wnl.41.11.1741.
Glantz MJ, Burger PC, Herndon JE, Friedman AH, Cairncross JG, Vick NA, et al. Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas. Neurology. 1991 Nov;41(11):1741–4.
Glantz, M. J., et al. “Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas.Neurology, vol. 41, no. 11, Nov. 1991, pp. 1741–44. Pubmed, doi:10.1212/wnl.41.11.1741.
Glantz MJ, Burger PC, Herndon JE, Friedman AH, Cairncross JG, Vick NA, Schold SC. Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas. Neurology. 1991 Nov;41(11):1741–1744.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

November 1991

Volume

41

Issue

11

Start / End Page

1741 / 1744

Location

United States

Related Subject Headings

  • Stereotaxic Techniques
  • Sex Factors
  • Sensitivity and Specificity
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Glioblastoma
  • Functional Laterality
  • Female