Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas.

Journal Article (Journal Article)

Stereotactic biopsy of CNS tumors provides a small amount of tissue for pathologic diagnosis. This potentially leads to inaccurate grading of gliomas because of their histologic heterogeneity. We compared histologic diagnoses in a consecutive series of 329 patients with newly diagnosed anaplastic gliomas whose diagnoses were established by either stereotactic biopsy or open resection. Of 262 patients undergoing resection, 214 (82%) had glioblastomas and 48 (18%) had anaplastic astrocytomas (AAs). Of 67 patients undergoing stereotactic biopsy, 33 (49%) had glioblastomas and 34 (51%) had AAs. This difference suggests that some AAs diagnosed by stereotactic biopsy are actually glioblastomas and has important implications for the design and interpretation of clinical trials.

Full Text

Duke Authors

Cited Authors

  • Glantz, MJ; Burger, PC; Herndon, JE; Friedman, AH; Cairncross, JG; Vick, NA; Schold, SC

Published Date

  • November 1991

Published In

Volume / Issue

  • 41 / 11

Start / End Page

  • 1741 - 1744

PubMed ID

  • 1658684

Pubmed Central ID

  • 1658684

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.41.11.1741


  • eng

Conference Location

  • United States