Induction paclitaxel/carboplatin followed by concurrent chemoradiation therapy for unresectable stage III non-small-cell lung cancer: a limited-access study--CALGB 9534.


Journal Article

BACKGROUND: This phase II cooperative group study of patients with unresectable stage III non-small-cell lung cancer was designed to treat patients with induction chemotherapy with paclitaxel and carboplatin (PC) followed by concurrent chemotherapy with the same chemotherapy plus thoracic irradiation to 66 Gy. PATIENTS AND METHODS: All enrolled patients were scheduled to receive 2 cycles of induction PC at conventional doses. All nonprogressing patients were subsequently treated with concurrent chemoradiation, including 7 weekly doses of PC and once-daily thoracic irradiation. The eligibility criteria allowed treatment of an expanded population of patients, unrestricted by previous weight loss. RESULTS: Despite the fact that 22% of patients had experienced > 5% weight loss in the preceding 6 months, 23 of the 40 eligible patients (58%) responded to the overall regimen. A 3-year failure-free survival rate of 15% and a 3-year overall survival rate of 27% were achieved. The 3-year overall survival rate is consistent with landmark cooperative group results for the combined modality treatment of a more highly selected patient population. CONCLUSION: The feasibility of this therapeutic approach in a cooperative group setting and inclusive of patients who were representative of the general population of stage III lung cancer patients was established.

Full Text

Duke Authors

Cited Authors

  • Akerley, W; Herndon, JE; Lyss, AP; Choy, H; Turrisi, A; Graziano, S; Williams, T; Zhang, C; Vokes, EE; Green, MR

Published Date

  • July 2005

Published In

Volume / Issue

  • 7 / 1

Start / End Page

  • 47 - 53

PubMed ID

  • 16098244

Pubmed Central ID

  • 16098244

International Standard Serial Number (ISSN)

  • 1525-7304

Digital Object Identifier (DOI)

  • 10.3816/CLC.2005.n.021


  • eng

Conference Location

  • United States