Evaluation and characterization of generalized anxiety and depression in patients with primary brain tumors.

Journal Article (Journal Article)

To determine clinical and sociodemographic factors that are associated with major neuropsychiatric illnesses among brain tumor patients, we administered a modified version of the Brief Patient Health Questionnaire and a demographic data form to 363 adult neuro-oncology patients. Responses were analyzed to assess for associations between demographic variables, clinical variables, and symptoms consistent with diagnoses of generalized anxiety disorder and/or depression. Multivariate logistic regression analyses showed that female gender was associated with the presence of symptoms of anxiety, depression, and combined anxiety and depression. Lower WHO tumor grade classifications, lower education level, and a history of psychiatric illness also emerged as important predictors of symptoms consistent with anxiety and/or depression. Marital status and presence of past/current medical illness trended toward being significantly associated with depression alone. Patient use of psychiatric medication was not associated with any study variables. Results of the present study suggest several hypotheses to test with neuro-oncology patients in further longitudinal analyses, which would benefit from the inclusion of a wider range of neuropsychiatric symptoms in conjunction with neurocognitive and functional impairment variables.

Full Text

Duke Authors

Cited Authors

  • Arnold, SD; Forman, LM; Brigidi, BD; Carter, KE; Schweitzer, HA; Quinn, HE; Guill, AB; Herndon, JE; Raynor, RH

Published Date

  • April 2008

Published In

Volume / Issue

  • 10 / 2

Start / End Page

  • 171 - 181

PubMed ID

  • 18314416

Pubmed Central ID

  • PMC2613819

International Standard Serial Number (ISSN)

  • 1522-8517

Digital Object Identifier (DOI)

  • 10.1215/15228517-2007-057


  • eng

Conference Location

  • England