Applying a conceptual model for examining health-related quality of life in long-term breast cancer survivors: CALGB study 79804.

Journal Article (Journal Article)

OBJECTIVES: The Survivor's Health and Reaction study used a quality-of-life model adapted for cancer survivors by Dow and colleagues to identify factors related to global health-related quality of life (HRQL) and to document the prevalence of problems and health-oriented behaviors in a follow-up study of breast cancer patients who participated in CALGB 8541. METHODS: A total of 245 survivors (78% of those invited) who were 9.4-16.5 years post-diagnosis completed surveys that inquired about current HRQL, economic, spiritual, physical and psychosocial concerns, and health-oriented behaviors (e.g. smoking, exercise, and supplement use). A regression model was developed to examine factors related to global HRQL across all domains. RESULTS: The regression model revealed that decreased energy levels (odds ratio (OR)=1.05, 95% confidence interval (CI): 1.03, 1.07), having heart disease (OR=5.01, 95% CI: 1.39, 18.1), having two or more co-morbidities (OR=2.39, 95% CI: 1.10, 5.19), and lower social support (OR=1.03, 95% CI: 1.02, 1.05) were associated with lower global HRQL. Factors related to psychological, spiritual, and economic domains were not predictive of global HRQL. Regarding lifestyle changes, some women reported engaging in health-oriented behaviors since their cancer diagnosis, such as improving eating habits (54%), increasing exercise (32%), and reducing/quitting smoking (20%). The most prevalent problems reported by women at follow-up were menopausal symptoms (64%), such as hot flashes and vaginal dryness, osteoporosis (25%), and lymphedema (23%). CONCLUSION: Suggestions are provided to target interventions, such as provider-based strategies, in order to improve HRQL in long-term breast cancer survivors.

Full Text

Duke Authors

Cited Authors

  • Paskett, ED; Herndon, JE; Day, JM; Stark, NN; Winer, EP; Grubbs, SS; Pavy, MD; Shapiro, CL; List, MA; Hensley, ML; Naughton, MA; Kornblith, AB; Habin, KR; Fleming, GF; Bittoni, MA; Cancer and Leukemia Group B,

Published Date

  • November 2008

Published In

Volume / Issue

  • 17 / 11

Start / End Page

  • 1108 - 1120

PubMed ID

  • 18314912

Pubmed Central ID

  • PMC3930158

Electronic International Standard Serial Number (EISSN)

  • 1099-1611

Digital Object Identifier (DOI)

  • 10.1002/pon.1329


  • eng

Conference Location

  • England