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The health-related quality of life and survival of small-cell lung cancer patients: results of a companion study to CALGB 9033.

Publication ,  Journal Article
Naughton, MJ; Herndon, JE; Shumaker, SA; Miller, AA; Kornblith, AB; Chao, D; Holland, J
Published in: Qual Life Res
May 2002

The purposes of this study were 2-fold: to evaluate the impact of the schedule dependency of etoposide (3-day IV short course vs. a 21-day oral prolonged course) with cisplatin on the quality of life of small-cell lung cancer (SCLC) patients; and to examine the effect of baseline quality of life variables on long-term survival, after adjustment for known demographic and clinical prognostic factors. Participants were 70 patients enrolled in the cancer and leukemia group B (CALGB) protocol 9033. Quality of life was assessed at baseline, 6 and 12 weeks by: the EORTC QLQ-30, the Centers for epidemiology studies--Depression short form, the medical outcomes study (MOS) social support questionnaire, and a scale of sleep quality. Contrary to expectations, study results suggested no significant differences in the patients' life quality and treatment response based on whether they received etoposide in a 3-day IV vs. a 21-day oral regimen. The use of the baseline variables in predicting overall survival indicated that patients who were non-white and with liver involvement had decreased survival. Brain involvement, being male, and higher depressive symptoms were also found to be borderline significant in predicting decreased survival in this patient population.

Duke Scholars

Published In

Qual Life Res

DOI

ISSN

0962-9343

Publication Date

May 2002

Volume

11

Issue

3

Start / End Page

235 / 248

Location

Netherlands

Related Subject Headings

  • Survival Rate
  • Surveys and Questionnaires
  • Quality of Life
  • Proportional Hazards Models
  • Prognosis
  • Middle Aged
  • Male
  • Linear Models
  • Humans
  • Health Policy & Services
 

Citation

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Naughton, M. J., Herndon, J. E., Shumaker, S. A., Miller, A. A., Kornblith, A. B., Chao, D., & Holland, J. (2002). The health-related quality of life and survival of small-cell lung cancer patients: results of a companion study to CALGB 9033. Qual Life Res, 11(3), 235–248. https://doi.org/10.1023/a:1015257121369
Naughton, M. J., J. E. Herndon, S. A. Shumaker, A. A. Miller, A. B. Kornblith, D. Chao, and J. Holland. “The health-related quality of life and survival of small-cell lung cancer patients: results of a companion study to CALGB 9033.Qual Life Res 11, no. 3 (May 2002): 235–48. https://doi.org/10.1023/a:1015257121369.
Naughton MJ, Herndon JE, Shumaker SA, Miller AA, Kornblith AB, Chao D, et al. The health-related quality of life and survival of small-cell lung cancer patients: results of a companion study to CALGB 9033. Qual Life Res. 2002 May;11(3):235–48.
Naughton, M. J., et al. “The health-related quality of life and survival of small-cell lung cancer patients: results of a companion study to CALGB 9033.Qual Life Res, vol. 11, no. 3, May 2002, pp. 235–48. Pubmed, doi:10.1023/a:1015257121369.
Naughton MJ, Herndon JE, Shumaker SA, Miller AA, Kornblith AB, Chao D, Holland J. The health-related quality of life and survival of small-cell lung cancer patients: results of a companion study to CALGB 9033. Qual Life Res. 2002 May;11(3):235–248.
Journal cover image

Published In

Qual Life Res

DOI

ISSN

0962-9343

Publication Date

May 2002

Volume

11

Issue

3

Start / End Page

235 / 248

Location

Netherlands

Related Subject Headings

  • Survival Rate
  • Surveys and Questionnaires
  • Quality of Life
  • Proportional Hazards Models
  • Prognosis
  • Middle Aged
  • Male
  • Linear Models
  • Humans
  • Health Policy & Services