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Effect of megestrol acetate on quality of life in a dose-response trial in women with advanced breast cancer. The Cancer and Leukemia Group B.

Publication ,  Journal Article
Kornblith, AB; Hollis, DR; Zuckerman, E; Lyss, AP; Canellos, GP; Cooper, MR; Herndon, JE; Phillips, CA; Abrams, J; Aisner, J
Published in: J Clin Oncol
November 1993

PURPOSE: The impact of the side effects of megestrol acetate on the quality of life of noncachectic women with advanced breast cancer was studied in a dose-response clinical trial of the Cancer and Leukemia Group B (CALGB 8741). Side effects of appetite increase and weight gain at higher doses were predicted to have a negative effect on quality of life. PATIENTS AND METHODS: Stage IV breast cancer patients were randomized to receive either 160, 800, or 1,600 mg/d of megestrol acetate. Quality of life was assessed in 131 patients at trial entry and at 1 and 3 months while on treatment, by telephone interview, using the following measures: the Functional Living Index-Cancer (FLIC), Rand Functional Limitations Scale, Rand Mental Health Inventory (MHI), the Body Image Subscale, and linear analog scales of drug side effects. RESULTS: At 3 months, women treated with 160 mg/d reported less severe side effects (P < .0005), better physical functioning (FLS, P < .0005), less psychologic distress (MHI, P = .008), and an improvement in overall quality of life (FLIC, P = .003) from the time of study entry as compared with those treated with 1,600 mg/d. Patients who received the 800-mg/d dose fell between the low- and high-dose arms in reported intensity of drug side effects, but responded similarly to those in the 160-mg/d group in terms of physical functioning, psychologic distress, and overall quality of life. CONCLUSION: Unless additional follow-up data demonstrate a survival advantage at higher doses, the 160-mg/d dose is optimal, achieving maximal treatment effect with the fewest side effects and better quality of life.

Duke Scholars

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Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

November 1993

Volume

11

Issue

11

Start / End Page

2081 / 2089

Location

United States

Related Subject Headings

  • Weight Gain
  • Treatment Outcome
  • Quality of Life
  • Oncology & Carcinogenesis
  • Multivariate Analysis
  • Middle Aged
  • Megestrol Acetate
  • Megestrol
  • Linear Models
  • Humans
 

Citation

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Kornblith, A. B., Hollis, D. R., Zuckerman, E., Lyss, A. P., Canellos, G. P., Cooper, M. R., … Aisner, J. (1993). Effect of megestrol acetate on quality of life in a dose-response trial in women with advanced breast cancer. The Cancer and Leukemia Group B. J Clin Oncol, 11(11), 2081–2089. https://doi.org/10.1200/JCO.1993.11.11.2081
Kornblith, A. B., D. R. Hollis, E. Zuckerman, A. P. Lyss, G. P. Canellos, M. R. Cooper, J. E. Herndon, C. A. Phillips, J. Abrams, and J. Aisner. “Effect of megestrol acetate on quality of life in a dose-response trial in women with advanced breast cancer. The Cancer and Leukemia Group B.J Clin Oncol 11, no. 11 (November 1993): 2081–89. https://doi.org/10.1200/JCO.1993.11.11.2081.
Kornblith AB, Hollis DR, Zuckerman E, Lyss AP, Canellos GP, Cooper MR, et al. Effect of megestrol acetate on quality of life in a dose-response trial in women with advanced breast cancer. The Cancer and Leukemia Group B. J Clin Oncol. 1993 Nov;11(11):2081–9.
Kornblith, A. B., et al. “Effect of megestrol acetate on quality of life in a dose-response trial in women with advanced breast cancer. The Cancer and Leukemia Group B.J Clin Oncol, vol. 11, no. 11, Nov. 1993, pp. 2081–89. Pubmed, doi:10.1200/JCO.1993.11.11.2081.
Kornblith AB, Hollis DR, Zuckerman E, Lyss AP, Canellos GP, Cooper MR, Herndon JE, Phillips CA, Abrams J, Aisner J. Effect of megestrol acetate on quality of life in a dose-response trial in women with advanced breast cancer. The Cancer and Leukemia Group B. J Clin Oncol. 1993 Nov;11(11):2081–2089.

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

November 1993

Volume

11

Issue

11

Start / End Page

2081 / 2089

Location

United States

Related Subject Headings

  • Weight Gain
  • Treatment Outcome
  • Quality of Life
  • Oncology & Carcinogenesis
  • Multivariate Analysis
  • Middle Aged
  • Megestrol Acetate
  • Megestrol
  • Linear Models
  • Humans