A phase II study of recombinant beta-interferon at maximum tolerated dose in patients with advanced non-small cell lung cancer: a cancer and leukemia group B study.

Journal Article (Clinical Trial;Journal Article)

Forty-one patients with advanced non-small cell lung cancer (NSCLC) were entered into a phase II study of high dose recombinant interferon (rIFN)-beta. Patients received intravenous (i.v.) rIFN-beta on a Monday, Wednesday, Friday schedule with a weekly dose escalation until > or = grade 3 toxicity or 720 x 10(6) IU/dose was achieved. Thirty-eight patients were eligible. Seventeen patients received the highest planned dose of rIFN-beta and 11 experienced dose-limiting toxicity at lower doses. Ten patients developed progressive disease before grade 3 toxicity was reached. There were no objective responses observed. Significant and dose-limiting toxicities included nausea and vomiting, fever, rigors, severe dyspnea, hypotension, and hypertension. IFN-beta has no measurable antitumor activity against NSCLC even at maximum tolerated doses (MTDs).

Full Text

Duke Authors

Cited Authors

  • Wheeler, RH; Herndon, JE; Clamon, GH; Green, MR

Published Date

  • April 1, 1994

Published In

Volume / Issue

  • 15 / 3

Start / End Page

  • 212 - 216

PubMed ID

  • 8032544

International Standard Serial Number (ISSN)

  • 1067-5582

Digital Object Identifier (DOI)

  • 10.1097/00002371-199404000-00007


  • eng

Conference Location

  • United States