Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB.

Journal Article (Journal Article)

Migration of airway epithelial cells (AEC) is a necessary component of airway mucosal repair after injury. The cytokine IL-1beta, present in airway inflammation, has protean effects on constituent cells within the mucosa, but its effects on epithelial repair are not known. We examined migration in differentiated primary human AEC grown in air-liquid interface culture for up to 3 wk and in the 16HBE14o(-) cell line. Wounds were created by mechanical abrasion and followed to closure using digital microscopy. Concurrent treatment with IL-1beta (

Full Text

Duke Authors

Cited Authors

  • White, SR; Fischer, BM; Marroquin, BA; Stern, R

Published Date

  • December 2008

Published In

Volume / Issue

  • 295 / 6

Start / End Page

  • L1018 - L1027

PubMed ID

  • 18849440

Pubmed Central ID

  • PMC2604797

International Standard Serial Number (ISSN)

  • 1040-0605

Digital Object Identifier (DOI)

  • 10.1152/ajplung.00065.2008


  • eng

Conference Location

  • United States