Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB.
Journal Article (Journal Article)
Migration of airway epithelial cells (AEC) is a necessary component of airway mucosal repair after injury. The cytokine IL-1beta, present in airway inflammation, has protean effects on constituent cells within the mucosa, but its effects on epithelial repair are not known. We examined migration in differentiated primary human AEC grown in air-liquid interface culture for up to 3 wk and in the 16HBE14o(-) cell line. Wounds were created by mechanical abrasion and followed to closure using digital microscopy. Concurrent treatment with IL-1beta (
Full Text
Duke Authors
Cited Authors
- White, SR; Fischer, BM; Marroquin, BA; Stern, R
Published Date
- December 2008
Published In
Volume / Issue
- 295 / 6
Start / End Page
- L1018 - L1027
PubMed ID
- 18849440
Pubmed Central ID
- PMC2604797
International Standard Serial Number (ISSN)
- 1040-0605
Digital Object Identifier (DOI)
- 10.1152/ajplung.00065.2008
Language
- eng
Conference Location
- United States