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Pharmacogenomics and end-organ susceptibility to injury in the perioperative period.

Publication ,  Journal Article
Schwinn, DA; Podgoreanu, M
Published in: Best Pract Res Clin Anaesthesiol
March 2008

Genomic medicine has provided new mechanistic understanding for many complex diseases over the last 5-10 years. More recently genomic approaches have been applied to the perioperative paradigm, facilitating identification of patients at high risk for adverse events, as well as those who will respond better/worse to specific pharmacologic therapies. The consistent biological theme emerging is that while inflammation is important in healing from surgical trauma, patients who are too robustly proinflammatory appear to be at higher risk for adverse perioperative events. Precise predictors of each adverse event are being elucidated so that corrective therapeutics can be instituted to improve outcomes in high-risk patients. While the field of perioperative genomics could be considered in its infancy, such approaches are the wave of the future.

Duke Scholars

Published In

Best Pract Res Clin Anaesthesiol

DOI

ISSN

1753-3740

Publication Date

March 2008

Volume

22

Issue

1

Start / End Page

23 / 37

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Postoperative Complications
  • Polymorphism, Single Nucleotide
  • Pharmacogenetics
  • Perioperative Care
  • Intraoperative Complications
  • Humans
  • Genomics
  • Genetic Variation
  • Anesthesiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schwinn, D. A., & Podgoreanu, M. (2008). Pharmacogenomics and end-organ susceptibility to injury in the perioperative period. Best Pract Res Clin Anaesthesiol, 22(1), 23–37. https://doi.org/10.1016/j.bpa.2007.09.005
Schwinn, Debra A., and Mihai Podgoreanu. “Pharmacogenomics and end-organ susceptibility to injury in the perioperative period.Best Pract Res Clin Anaesthesiol 22, no. 1 (March 2008): 23–37. https://doi.org/10.1016/j.bpa.2007.09.005.
Schwinn DA, Podgoreanu M. Pharmacogenomics and end-organ susceptibility to injury in the perioperative period. Best Pract Res Clin Anaesthesiol. 2008 Mar;22(1):23–37.
Schwinn, Debra A., and Mihai Podgoreanu. “Pharmacogenomics and end-organ susceptibility to injury in the perioperative period.Best Pract Res Clin Anaesthesiol, vol. 22, no. 1, Mar. 2008, pp. 23–37. Pubmed, doi:10.1016/j.bpa.2007.09.005.
Schwinn DA, Podgoreanu M. Pharmacogenomics and end-organ susceptibility to injury in the perioperative period. Best Pract Res Clin Anaesthesiol. 2008 Mar;22(1):23–37.
Journal cover image

Published In

Best Pract Res Clin Anaesthesiol

DOI

ISSN

1753-3740

Publication Date

March 2008

Volume

22

Issue

1

Start / End Page

23 / 37

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Postoperative Complications
  • Polymorphism, Single Nucleotide
  • Pharmacogenetics
  • Perioperative Care
  • Intraoperative Complications
  • Humans
  • Genomics
  • Genetic Variation
  • Anesthesiology