Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis.

Journal Article (Journal Article;Review)

Subpopulations of individuals with alcohol-induced fatty livers and nonalcoholic steatosis develop steatohepatitis. Steatohepatitis is defined histologically: increased numbers of injured and dying hepatocytes distinguish this condition from simple steatosis. The increased hepatocyte death is generally accompanied by hepatic accumulation of inflammatory cells and sometimes increases in myofibroblastic cells, leading to hepatic fibrosis and eventually, cirrhosis. The purpose of this review is to summarize similarities and differences in the pathogenesis of steatohepatitis in alcoholic fatty liver disease and nonalcoholic fatty liver disease.

Full Text

Duke Authors

Cited Authors

  • Syn, W-K; Teaberry, V; Choi, SS; Diehl, AM

Published Date

  • May 2009

Published In

Volume / Issue

  • 29 / 2

Start / End Page

  • 200 - 210

PubMed ID

  • 19387919

Pubmed Central ID

  • PMC3644873

Electronic International Standard Serial Number (EISSN)

  • 1098-8971

Digital Object Identifier (DOI)

  • 10.1055/s-0029-1214375


  • eng

Conference Location

  • United States