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Randomized controlled trial of feeding a concentrated formula to infants born to women infected by human immunodeficiency virus.

Publication ,  Journal Article
Winter, HS; Oleske, JM; Hughes, MD; McKinney, RE; Elgie, C; Powell, C; Purdue, L; Puga, AM; Jimenez, E; Scott, GB; Cruz, MLS; Moye, J ...
Published in: J Pediatr Gastroenterol Nutr
August 2009

OBJECTIVE: We tested the hypothesis that concentrated formula (CF) begun within the first 2 weeks of life increases growth in infants born to human immunodeficiency virus (HIV)-infected mothers. MATERIALS AND METHODS: HIV-exposed infants from the United States, the Bahamas, and Brazil were randomized in a double-blind, controlled trial to receive either a CF (87 kcal/100 mL [26 kcal/oz]) or a standard formula (SF; 67 kcal/100 mL [20 kcal/oz]) for 8 weeks. This article presents results for infants who were not determined to be HIV infected based on testing at 4 weeks. Primary outcomes were safety, tolerability, and growth in weight and length. RESULTS: Two thousand ninety-seven infants were enrolled, of whom 1998 were uninfected and had study formula dispensed. At weeks 4 and 8, uninfected infants receiving CF showed higher energy intake than those who were receiving SF (P < 0.001). By week 8, uninfected infants assigned to CF weighed more than infants receiving SF. There were no consistent differences in measures of tolerability, and rates of discontinuation or perceived formula intolerance were similar between treatment groups. CONCLUSIONS: A CF is well tolerated and results in increased weight gain compared with SF. Until the HIV status of an infant is reliably determined, early introduction of a CF in HIV-exposed children may have beneficial effects on growth. The role of early nutritional intervention remains to be determined for individuals living in countries with endemic malnutrition for whom formula feeding is a viable option.

Duke Scholars

Published In

J Pediatr Gastroenterol Nutr

DOI

EISSN

1536-4801

Publication Date

August 2009

Volume

49

Issue

2

Start / End Page

222 / 232

Location

United States

Related Subject Headings

  • Weight Gain
  • United States
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Milk
  • Infant, Newborn
  • Infant Formula
  • Infant
  • Humans
  • HIV Infections
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Winter, H. S., Oleske, J. M., Hughes, M. D., McKinney, R. E., Elgie, C., Powell, C., … Pediatric AIDS Clinical Trials Group Protocol 247 Study Team, . (2009). Randomized controlled trial of feeding a concentrated formula to infants born to women infected by human immunodeficiency virus. J Pediatr Gastroenterol Nutr, 49(2), 222–232. https://doi.org/10.1097/MPG.0b013e3181928937
Winter, Harland S., James M. Oleske, Michael D. Hughes, Ross E. McKinney, Carol Elgie, Christine Powell, Lynette Purdue, et al. “Randomized controlled trial of feeding a concentrated formula to infants born to women infected by human immunodeficiency virus.J Pediatr Gastroenterol Nutr 49, no. 2 (August 2009): 222–32. https://doi.org/10.1097/MPG.0b013e3181928937.
Winter HS, Oleske JM, Hughes MD, McKinney RE, Elgie C, Powell C, et al. Randomized controlled trial of feeding a concentrated formula to infants born to women infected by human immunodeficiency virus. J Pediatr Gastroenterol Nutr. 2009 Aug;49(2):222–32.
Winter, Harland S., et al. “Randomized controlled trial of feeding a concentrated formula to infants born to women infected by human immunodeficiency virus.J Pediatr Gastroenterol Nutr, vol. 49, no. 2, Aug. 2009, pp. 222–32. Pubmed, doi:10.1097/MPG.0b013e3181928937.
Winter HS, Oleske JM, Hughes MD, McKinney RE, Elgie C, Powell C, Purdue L, Puga AM, Jimenez E, Scott GB, Cruz MLS, Moye J, Pediatric AIDS Clinical Trials Group Protocol 247 Study Team. Randomized controlled trial of feeding a concentrated formula to infants born to women infected by human immunodeficiency virus. J Pediatr Gastroenterol Nutr. 2009 Aug;49(2):222–232.

Published In

J Pediatr Gastroenterol Nutr

DOI

EISSN

1536-4801

Publication Date

August 2009

Volume

49

Issue

2

Start / End Page

222 / 232

Location

United States

Related Subject Headings

  • Weight Gain
  • United States
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Milk
  • Infant, Newborn
  • Infant Formula
  • Infant
  • Humans
  • HIV Infections