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Effect of high doses of intravenously administered immune globulin on natural killer cell activity in peripheral blood.

Publication ,  Journal Article
Finberg, RW; Newburger, JW; Mikati, MA; Heller, AH; Burns, JC
Published in: J Pediatr
March 1992

Because Kawasaki disease is a disorder characterized by lymphocyte activation and immune complex destruction of endothelial cells, we examined the effect of administration of high doses of intravenously administered immune globulin (IVIG) on a lymphocyte population with affinity for endothelial cells: the natural killer cells. We found that administration of high doses of IVIG resulted in a significant increase in the activity of natural killer cells and in the numbers of circulating CD16+ cells. Furthermore, a study of patients treated with IVIG for seizure disorders suggests that this effect of IVIG on circulating NK cells is not unique to patients with Kawasaki disease. The beneficial effect of IVIG in the treatment of Kawasaki disease may be due to the ability of IVIG to inhibit interaction between natural killer cells and endothelial cells.

Duke Scholars

Published In

J Pediatr

DOI

ISSN

0022-3476

Publication Date

March 1992

Volume

120

Issue

3

Start / End Page

376 / 380

Location

United States

Related Subject Headings

  • Pediatrics
  • Mucocutaneous Lymph Node Syndrome
  • Killer Cells, Natural
  • Immunoglobulins, Intravenous
  • Immunoglobulin G
  • Humans
  • Epilepsy
  • Child
  • Antibody-Dependent Cell Cytotoxicity
  • 3213 Paediatrics
 

Citation

APA
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ICMJE
MLA
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Finberg, R. W., Newburger, J. W., Mikati, M. A., Heller, A. H., & Burns, J. C. (1992). Effect of high doses of intravenously administered immune globulin on natural killer cell activity in peripheral blood. J Pediatr, 120(3), 376–380. https://doi.org/10.1016/s0022-3476(05)80900-x
Finberg, R. W., J. W. Newburger, M. A. Mikati, A. H. Heller, and J. C. Burns. “Effect of high doses of intravenously administered immune globulin on natural killer cell activity in peripheral blood.J Pediatr 120, no. 3 (March 1992): 376–80. https://doi.org/10.1016/s0022-3476(05)80900-x.
Finberg RW, Newburger JW, Mikati MA, Heller AH, Burns JC. Effect of high doses of intravenously administered immune globulin on natural killer cell activity in peripheral blood. J Pediatr. 1992 Mar;120(3):376–80.
Finberg, R. W., et al. “Effect of high doses of intravenously administered immune globulin on natural killer cell activity in peripheral blood.J Pediatr, vol. 120, no. 3, Mar. 1992, pp. 376–80. Pubmed, doi:10.1016/s0022-3476(05)80900-x.
Finberg RW, Newburger JW, Mikati MA, Heller AH, Burns JC. Effect of high doses of intravenously administered immune globulin on natural killer cell activity in peripheral blood. J Pediatr. 1992 Mar;120(3):376–380.
Journal cover image

Published In

J Pediatr

DOI

ISSN

0022-3476

Publication Date

March 1992

Volume

120

Issue

3

Start / End Page

376 / 380

Location

United States

Related Subject Headings

  • Pediatrics
  • Mucocutaneous Lymph Node Syndrome
  • Killer Cells, Natural
  • Immunoglobulins, Intravenous
  • Immunoglobulin G
  • Humans
  • Epilepsy
  • Child
  • Antibody-Dependent Cell Cytotoxicity
  • 3213 Paediatrics