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Correlation of 99mTc-HMPAO SPECT with EEG monitoring: prognostic value for outcome of epilepsy surgery in children.

Publication ,  Journal Article
Lynch, BJ; O'Tuama, LA; Treves, ST; Mikati, M; Holmes, GL
Published in: Brain Dev
1995

Sixteen children who had focal cortical resections for medically intractable epilepsy were preoperatively evaluated with 99mtechnetium-labelled hexamethylpropyleneamineoxime single photon emission computed tomography (99mTc-HMPAO SPECT). Video-EEG monitoring was performed in all patients. Outcome was assessed according to the criteria of Engel et al. [1], at a mean follow up length of 13.4 +/- 8.7 months, in all patients. Interictal SPECT showed appropriate localization in 11/15 cases, of whom nine had a class 1 outcome and two had class 2 and 4 outcomes. Interictal SPECT did not correlate with ictal EEG in 4/15 patients, of whom two had a class 1 outcome, and two had class 3 and 4 outcomes. Two postictal studies obtained in group I showed good correlation with the area of ictal EEG onset, and both patients had a class 1 outcome. Interictal HMPAO SPECT imaging, when positively correlated with the ictal EEG focus or with the site of surgery determined by other means, may have prognostic value for outcome of cortical resections for epilepsy in children. The use of ictal and post-ictal studies shows promise for further improving prognostic information in this population.

Duke Scholars

Published In

Brain Dev

DOI

ISSN

0387-7604

Publication Date

1995

Volume

17

Issue

6

Start / End Page

409 / 417

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Tomography, Emission-Computed, Single-Photon
  • Technetium Tc 99m Exametazime
  • Prognosis
  • Predictive Value of Tests
  • Oximes
  • Organotechnetium Compounds
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Male
 

Citation

APA
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ICMJE
MLA
NLM
Lynch, B. J., O’Tuama, L. A., Treves, S. T., Mikati, M., & Holmes, G. L. (1995). Correlation of 99mTc-HMPAO SPECT with EEG monitoring: prognostic value for outcome of epilepsy surgery in children. Brain Dev, 17(6), 409–417. https://doi.org/10.1016/0387-7604(95)00066-6
Lynch, B. J., L. A. O’Tuama, S. T. Treves, M. Mikati, and G. L. Holmes. “Correlation of 99mTc-HMPAO SPECT with EEG monitoring: prognostic value for outcome of epilepsy surgery in children.Brain Dev 17, no. 6 (1995): 409–17. https://doi.org/10.1016/0387-7604(95)00066-6.
Lynch BJ, O’Tuama LA, Treves ST, Mikati M, Holmes GL. Correlation of 99mTc-HMPAO SPECT with EEG monitoring: prognostic value for outcome of epilepsy surgery in children. Brain Dev. 1995;17(6):409–17.
Lynch, B. J., et al. “Correlation of 99mTc-HMPAO SPECT with EEG monitoring: prognostic value for outcome of epilepsy surgery in children.Brain Dev, vol. 17, no. 6, 1995, pp. 409–17. Pubmed, doi:10.1016/0387-7604(95)00066-6.
Lynch BJ, O’Tuama LA, Treves ST, Mikati M, Holmes GL. Correlation of 99mTc-HMPAO SPECT with EEG monitoring: prognostic value for outcome of epilepsy surgery in children. Brain Dev. 1995;17(6):409–417.
Journal cover image

Published In

Brain Dev

DOI

ISSN

0387-7604

Publication Date

1995

Volume

17

Issue

6

Start / End Page

409 / 417

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Tomography, Emission-Computed, Single-Photon
  • Technetium Tc 99m Exametazime
  • Prognosis
  • Predictive Value of Tests
  • Oximes
  • Organotechnetium Compounds
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Male