Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain.

Journal Article (Journal Article)

Ten-day-old rat pups (P10) subjected to acute hypoxia (down to 4% O2) had as adults increased aggression (handling test), memory impairment (water maze test), and decreased CA1 cell counts. Pups subjected to chronic hypoxia (10% O2 from P0 to P21) had increased aggression, hyperactivity (open-field test), and decreased CA1 cell counts. Chronic hypoxia with superimposed acute hypoxia resulted in consequences that were not different from those of chronic hypoxia.

Full Text

Duke Authors

Cited Authors

  • Mikati, MA; Zeinieh, MP; Kurdi, RM; Harb, SA; El Hokayem, JA; Daderian, RH; Shamseddine, A; Obeid, M; Bitar, FF; El Sabban, M

Published Date

  • June 9, 2005

Published In

Volume / Issue

  • 157 / 1

Start / End Page

  • 98 - 102

PubMed ID

  • 15939090

International Standard Serial Number (ISSN)

  • 0165-3806

Digital Object Identifier (DOI)

  • 10.1016/j.devbrainres.2005.03.007


  • eng

Conference Location

  • Netherlands