Neuroprotective effect of chronic infusion of basic fibroblast growth factor on seizure-associated hippocampal damage.


Journal Article

Basic fibroblast growth factor (bFGF) has been shown to have neuroprotective effects in animal models of ischemia. To determine whether bFGF is protective against seizure-induced brain damage, we administered bFGF through osmotic pumps prior to, and after treatment with kainic acid (KA). Recombinant bFGF, CS23, a modified human bFGF, was infused into the lateral ventricles in rats for 2 days before and 5 days after the injection of KA. Control rats received equal volumes of phosphated saline over the same period of time. Infusion of 5 micrograms/ml of bFGF (0.5 microliter/h) did not modify the latency and duration of seizures induced by intraperitoneal injections of KA. However, bFGF prevented cell loss in the hippocampus in 80% of the rats. In control rats, cell loss in the hippocampus was found in all rats. These results indicate that bFGF has a substantial neuroprotective effect.

Full Text

Duke Authors

Cited Authors

  • Liu, Z; D'Amore, PA; Mikati, M; Gatt, A; Holmes, GL

Published Date

  • October 29, 1993

Published In

Volume / Issue

  • 626 / 1-2

Start / End Page

  • 335 - 338

PubMed ID

  • 8281447

Pubmed Central ID

  • 8281447

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(93)90598-h


  • eng

Conference Location

  • Netherlands