Neuroprotective effect of chronic infusion of basic fibroblast growth factor on seizure-associated hippocampal damage.

Journal Article (Journal Article)

Basic fibroblast growth factor (bFGF) has been shown to have neuroprotective effects in animal models of ischemia. To determine whether bFGF is protective against seizure-induced brain damage, we administered bFGF through osmotic pumps prior to, and after treatment with kainic acid (KA). Recombinant bFGF, CS23, a modified human bFGF, was infused into the lateral ventricles in rats for 2 days before and 5 days after the injection of KA. Control rats received equal volumes of phosphated saline over the same period of time. Infusion of 5 micrograms/ml of bFGF (0.5 microliter/h) did not modify the latency and duration of seizures induced by intraperitoneal injections of KA. However, bFGF prevented cell loss in the hippocampus in 80% of the rats. In control rats, cell loss in the hippocampus was found in all rats. These results indicate that bFGF has a substantial neuroprotective effect.

Full Text

Duke Authors

Cited Authors

  • Liu, Z; D'Amore, PA; Mikati, M; Gatt, A; Holmes, GL

Published Date

  • October 29, 1993

Published In

Volume / Issue

  • 626 / 1-2

Start / End Page

  • 335 - 338

PubMed ID

  • 8281447

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(93)90598-h


  • eng

Conference Location

  • Netherlands