Neuroprotective effect of chronic infusion of basic fibroblast growth factor on seizure-associated hippocampal damage.
Basic fibroblast growth factor (bFGF) has been shown to have neuroprotective effects in animal models of ischemia. To determine whether bFGF is protective against seizure-induced brain damage, we administered bFGF through osmotic pumps prior to, and after treatment with kainic acid (KA). Recombinant bFGF, CS23, a modified human bFGF, was infused into the lateral ventricles in rats for 2 days before and 5 days after the injection of KA. Control rats received equal volumes of phosphated saline over the same period of time. Infusion of 5 micrograms/ml of bFGF (0.5 microliter/h) did not modify the latency and duration of seizures induced by intraperitoneal injections of KA. However, bFGF prevented cell loss in the hippocampus in 80% of the rats. In control rats, cell loss in the hippocampus was found in all rats. These results indicate that bFGF has a substantial neuroprotective effect.
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- Seizures
- Rats, Sprague-Dawley
- Rats
- Pilot Projects
- Neurons
- Neurology & Neurosurgery
- Male
- Kainic Acid
- Infusion Pumps, Implantable
- Hippocampus
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Seizures
- Rats, Sprague-Dawley
- Rats
- Pilot Projects
- Neurons
- Neurology & Neurosurgery
- Male
- Kainic Acid
- Infusion Pumps, Implantable
- Hippocampus