Efficacy of intravenous immunoglobulin in Landau-Kleffner syndrome.


Journal Article

We administered 2 gm/kg of intravenous gamma globulin (IVIG) to each of five consecutive patients with Landau-Kleffner syndrome, over 4 days. We compared the 1-month baseline to that following IVIG using a severity score assessing speech, comprehension, behavior, seizures, and electroencephalography. There was a significant drop in this score after IVIG (P = 0.025). Two patients had a dramatic response to IVIG, with complete resolution of symptoms. This finding suggests that IVIG has at least some efficacy for the therapy of Landau-Kleffner syndrome.

Full Text

Duke Authors

Cited Authors

  • Mikati, MA; Saab, R; Fayad, MN; Choueiri, RN

Published Date

  • April 2002

Published In

Volume / Issue

  • 26 / 4

Start / End Page

  • 298 - 300

PubMed ID

  • 11992758

Pubmed Central ID

  • 11992758

International Standard Serial Number (ISSN)

  • 0887-8994

Digital Object Identifier (DOI)

  • 10.1016/s0887-8994(01)00402-7


  • eng

Conference Location

  • United States