Skip to main content
Journal cover image

Efficacy of gabapentin therapy in children with refractory partial seizures.

Publication ,  Journal Article
Khurana, DS; Riviello, J; Helmers, S; Holmes, G; Anderson, J; Mikati, MA
Published in: J Pediatr
June 1996

Thirty-two children with refractory partial epilepsy received open-label gabapentin as an additional medication to their antiepileptic drug regimen. Gabapentin was given in a dose ranging from 10 to 50 mg/kg per day (mean dose, 26.7 mg/kg daily). All patients had partial seizures with or without secondary generalization. Compared with baseline, 11 patients (34.4%) had a greater than 50% decrease in seizure frequency, and 4 (12.5%) had a 25% to 50% decrease in seizure frequency. Of the seven children who received the medication for 6 months or longer, two were seizure free and four were almost seizure free (having one seizure every few months). Mean gabapentin concentration was 4.8 micrograms/ml, and mean apparent clearance was 372 ml/kg per hour. The major reported side effects were behavioral. These consisted of hyperactivity, irritability, and agitation that occurred in patients with baseline mental retardation with attention deficit. We conclude that gabapentin can be a useful adjunctive medication in the treatment of refractory partial epilepsy in children.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Pediatr

DOI

ISSN

0022-3476

Publication Date

June 1996

Volume

128

Issue

6

Start / End Page

829 / 833

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Treatment Outcome
  • Pediatrics
  • Male
  • Infant
  • Humans
  • Gabapentin
  • Female
  • Epilepsies, Partial
  • Electroencephalography
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Khurana, D. S., Riviello, J., Helmers, S., Holmes, G., Anderson, J., & Mikati, M. A. (1996). Efficacy of gabapentin therapy in children with refractory partial seizures. J Pediatr, 128(6), 829–833. https://doi.org/10.1016/s0022-3476(96)70336-0
Khurana, D. S., J. Riviello, S. Helmers, G. Holmes, J. Anderson, and M. A. Mikati. “Efficacy of gabapentin therapy in children with refractory partial seizures.J Pediatr 128, no. 6 (June 1996): 829–33. https://doi.org/10.1016/s0022-3476(96)70336-0.
Khurana DS, Riviello J, Helmers S, Holmes G, Anderson J, Mikati MA. Efficacy of gabapentin therapy in children with refractory partial seizures. J Pediatr. 1996 Jun;128(6):829–33.
Khurana, D. S., et al. “Efficacy of gabapentin therapy in children with refractory partial seizures.J Pediatr, vol. 128, no. 6, June 1996, pp. 829–33. Pubmed, doi:10.1016/s0022-3476(96)70336-0.
Khurana DS, Riviello J, Helmers S, Holmes G, Anderson J, Mikati MA. Efficacy of gabapentin therapy in children with refractory partial seizures. J Pediatr. 1996 Jun;128(6):829–833.
Journal cover image

Published In

J Pediatr

DOI

ISSN

0022-3476

Publication Date

June 1996

Volume

128

Issue

6

Start / End Page

829 / 833

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Treatment Outcome
  • Pediatrics
  • Male
  • Infant
  • Humans
  • Gabapentin
  • Female
  • Epilepsies, Partial
  • Electroencephalography