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Facilitation of infantile spasms by partial seizures.

Publication ,  Journal Article
Carrazana, EJ; Lombroso, CT; Mikati, M; Helmers, S; Holmes, GL
Published in: Epilepsia
1993

We report 16 patients with infantile spasms in whom onset of the clusters of spasms appeared to be triggered by close temporal association with partial seizures. Common features included the presence of focal cerebral lesions in 12 infants (3 were classifiable as cryptogenic); all had partial seizures with EEG localization, clusters of bilateral spasms always preceded by partial seizures, and response to adrenocorticotropic hormone (ACTH) and traditional antiepileptic drugs (AEDs) generally was poor. Three had complete agenesis of the corpus callosum, which argues against interhemispheric callosal spread of focal discharges resulting in the generalized spasms. Surgical cortical resections were performed in 6 of the infants, with good outcomes. This group of patients supports a model in which the spasms, although probably generated at a subcortical level, are facilitated or possibly induced by focal discharges from cortical pathology.

Duke Scholars

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

1993

Volume

34

Issue

1

Start / End Page

97 / 109

Location

United States

Related Subject Headings

  • Spasms, Infantile
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Infant, Newborn
  • Infant
  • Humans
  • Female
  • Epilepsies, Partial
  • Electroencephalography
 

Citation

APA
Chicago
ICMJE
MLA
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Carrazana, E. J., Lombroso, C. T., Mikati, M., Helmers, S., & Holmes, G. L. (1993). Facilitation of infantile spasms by partial seizures. Epilepsia, 34(1), 97–109. https://doi.org/10.1111/j.1528-1157.1993.tb02381.x
Carrazana, E. J., C. T. Lombroso, M. Mikati, S. Helmers, and G. L. Holmes. “Facilitation of infantile spasms by partial seizures.Epilepsia 34, no. 1 (1993): 97–109. https://doi.org/10.1111/j.1528-1157.1993.tb02381.x.
Carrazana EJ, Lombroso CT, Mikati M, Helmers S, Holmes GL. Facilitation of infantile spasms by partial seizures. Epilepsia. 1993;34(1):97–109.
Carrazana, E. J., et al. “Facilitation of infantile spasms by partial seizures.Epilepsia, vol. 34, no. 1, 1993, pp. 97–109. Pubmed, doi:10.1111/j.1528-1157.1993.tb02381.x.
Carrazana EJ, Lombroso CT, Mikati M, Helmers S, Holmes GL. Facilitation of infantile spasms by partial seizures. Epilepsia. 1993;34(1):97–109.
Journal cover image

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

1993

Volume

34

Issue

1

Start / End Page

97 / 109

Location

United States

Related Subject Headings

  • Spasms, Infantile
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Infant, Newborn
  • Infant
  • Humans
  • Female
  • Epilepsies, Partial
  • Electroencephalography