Facilitation of infantile spasms by partial seizures.

Journal Article (Journal Article)

We report 16 patients with infantile spasms in whom onset of the clusters of spasms appeared to be triggered by close temporal association with partial seizures. Common features included the presence of focal cerebral lesions in 12 infants (3 were classifiable as cryptogenic); all had partial seizures with EEG localization, clusters of bilateral spasms always preceded by partial seizures, and response to adrenocorticotropic hormone (ACTH) and traditional antiepileptic drugs (AEDs) generally was poor. Three had complete agenesis of the corpus callosum, which argues against interhemispheric callosal spread of focal discharges resulting in the generalized spasms. Surgical cortical resections were performed in 6 of the infants, with good outcomes. This group of patients supports a model in which the spasms, although probably generated at a subcortical level, are facilitated or possibly induced by focal discharges from cortical pathology.

Full Text

Duke Authors

Cited Authors

  • Carrazana, EJ; Lombroso, CT; Mikati, M; Helmers, S; Holmes, GL

Published Date

  • 1993

Published In

Volume / Issue

  • 34 / 1

Start / End Page

  • 97 - 109

PubMed ID

  • 8422869

International Standard Serial Number (ISSN)

  • 0013-9580

Digital Object Identifier (DOI)

  • 10.1111/j.1528-1157.1993.tb02381.x


  • eng

Conference Location

  • United States