Localized morphea: a rare adverse effect of valproic acid.


Journal Article

Morphea, a specific type of cutaneous sclerosis, is known in the pediatric age group, but not as an adverse effect to the antiepileptic valproic acid. We report a 14-year-old male patient with absence seizures who, after treatment with valproic acid, developed skin tightness on the fingers. A biopsy specimen revealed dermal sclerosis consistent with morphea. His symptoms resolved gradually after discontinuation of the medication. To our knowledge, this is the first patient reported to have an apparently valproic acid-induced localized morphea.

Full Text

Duke Authors

Cited Authors

  • Ferzli, GT; El-Tal, AE-K; Kibbi, AG; Mikati, MA

Published Date

  • September 2003

Published In

Volume / Issue

  • 29 / 3

Start / End Page

  • 253 - 255

PubMed ID

  • 14629913

Pubmed Central ID

  • 14629913

International Standard Serial Number (ISSN)

  • 0887-8994

Digital Object Identifier (DOI)

  • 10.1016/s0887-8994(03)00214-5


  • eng

Conference Location

  • United States