Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance.


Journal Article

Addition of carbamazepine to phenytoin monotherapy resulted in the following significant (p less than 0.05) changes: (1) increased mean phenytoin serum concentration; (2) decreased phenytoin clearance, due to decreased production of phenytoin dihydrodiol and p-hydroxyphenyl-phenylhydantoin; (3) increased phenytoin elimination half-life; and (4) increased drug-related toxicity. Close monitoring is required after addition of carbamazepine to phenytoin.

Full Text

Duke Authors

Cited Authors

  • Browne, TR; Szabo, GK; Evans, JE; Evans, BA; Greenblatt, DJ; Mikati, MA

Published Date

  • July 1988

Published In

Volume / Issue

  • 38 / 7

Start / End Page

  • 1146 - 1150

PubMed ID

  • 3386835

Pubmed Central ID

  • 3386835

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.38.7.1146


  • eng

Conference Location

  • United States