Neuroprotective effect of felbamate after kainic acid-induced status epilepticus.

Published

Journal Article

Felbamate (FBM), a newly developed antiepileptic drug (AED), was previously shown to offer some neuroprotective effects against hypoxic injury in both in vivo and in vitro studies. We administered FBM (100 or 300 mg/kg) to 30-day-old rats 1 h after they received a convulsant dosage of kainic acid (KA). Animals were then tested at age 80 days in the water maze, open field, and handling tests. Seizure latency was then tested by flurothyl inhalation. Animals that received 300 mg/kg FBM performed better in all three tests and had longer latencies to flurothyl-induced seizures than did animals that received vehicle. This study suggests that FBM may have some neuroprotective effects after KA-induced status epilepticus (SE).

Full Text

Duke Authors

Cited Authors

  • Chronopoulos, A; Stafstrom, C; Thurber, S; Hyde, P; Mikati, M; Holmes, GL

Published Date

  • March 1, 1993

Published In

Volume / Issue

  • 34 / 2

Start / End Page

  • 359 - 366

PubMed ID

  • 8453945

Pubmed Central ID

  • 8453945

International Standard Serial Number (ISSN)

  • 0013-9580

Language

  • eng

Conference Location

  • United States