Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury.

Journal Article (Journal Article;Review)

Brain hypoxia-ischemia is a relatively common and serious problem in neonates and in adults. Its consequences include long-term histological and behavioral changes and reduction in seizure threshold. Gap junction intercellular communication is pivotal in the spread of hypoxia-ischemia related injury and in mediating its long-term effects. This review provides a comprehensive and critical review of hypoxia-ischemia and hypoxia in the brain and the potential role of gap junctions in the spread of the neuronal injury induced by these insults. It also presents the effects of hypoxia-ischemia and of hypoxia on the state of gap junctions in vitro and in vivo. Understanding the mechanisms involved in gap junction-mediated neuronal injury due to hypoxia will lead to the development of novel therapeutic strategies.

Full Text

Duke Authors

Cited Authors

  • Talhouk, RS; Zeinieh, MP; Mikati, MA; El-Sabban, ME

Published Date

  • January 2008

Published In

Volume / Issue

  • 84 / 1

Start / End Page

  • 57 - 76

PubMed ID

  • 18006137

International Standard Serial Number (ISSN)

  • 0301-0082

Digital Object Identifier (DOI)

  • 10.1016/j.pneurobio.2007.10.001


  • eng

Conference Location

  • England