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Transient hypertrophic cardiomyopathy in the newborn following multiple doses of antenatal corticosteroids.

Publication ,  Journal Article
Yunis, KA; Bitar, FF; Hayek, P; Mroueh, SM; Mikati, M
Published in: Am J Perinatol
1999

Postnatal exposure to steroids has been associated with hypertrophic cardiomyopathy (HCM) in the newborn. Such an effect has not been described in infants born to mothers who received antenatal steroids. We report three newborns whose mothers were treated with betamethasone prenatally in different doses, duration of time, and who developed various degrees of HCM diagnosed by echocardiography. There was no maternal evidence of diabetes except for one infant whose mother had a normal fasting and post-prandial blood glucose prior to steroid therapy, but an abnormal one hour postprandial glucose after 8 weeks of betamethasone therapy, with a normal HbA1 C level. There was no family history of HCM, no history of maternal intake of other relevant medications, and no hypertension in all three newborns. Follow-up echocardiography revealed complete resolution of the HCM changes in all infants. We suggest that repeated antenatal maternal steroid intake may cause changes of HCM in the newborn. These changes appear to be dose- and duration-related and are mostly reversible. Further prospective controlled studies to evaluate these observations and to investigate potential mechanisms are warranted.

Duke Scholars

Published In

Am J Perinatol

DOI

ISSN

0735-1631

Publication Date

1999

Volume

16

Issue

1

Start / End Page

17 / 21

Location

United States

Related Subject Headings

  • Prenatal Exposure Delayed Effects
  • Prenatal Care
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Obstetric Labor, Premature
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Glucocorticoids
  • Follow-Up Studies
 

Citation

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ICMJE
MLA
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Yunis, K. A., Bitar, F. F., Hayek, P., Mroueh, S. M., & Mikati, M. (1999). Transient hypertrophic cardiomyopathy in the newborn following multiple doses of antenatal corticosteroids. Am J Perinatol, 16(1), 17–21. https://doi.org/10.1055/s-2007-993830
Yunis, K. A., F. F. Bitar, P. Hayek, S. M. Mroueh, and M. Mikati. “Transient hypertrophic cardiomyopathy in the newborn following multiple doses of antenatal corticosteroids.Am J Perinatol 16, no. 1 (1999): 17–21. https://doi.org/10.1055/s-2007-993830.
Yunis KA, Bitar FF, Hayek P, Mroueh SM, Mikati M. Transient hypertrophic cardiomyopathy in the newborn following multiple doses of antenatal corticosteroids. Am J Perinatol. 1999;16(1):17–21.
Yunis, K. A., et al. “Transient hypertrophic cardiomyopathy in the newborn following multiple doses of antenatal corticosteroids.Am J Perinatol, vol. 16, no. 1, 1999, pp. 17–21. Pubmed, doi:10.1055/s-2007-993830.
Yunis KA, Bitar FF, Hayek P, Mroueh SM, Mikati M. Transient hypertrophic cardiomyopathy in the newborn following multiple doses of antenatal corticosteroids. Am J Perinatol. 1999;16(1):17–21.
Journal cover image

Published In

Am J Perinatol

DOI

ISSN

0735-1631

Publication Date

1999

Volume

16

Issue

1

Start / End Page

17 / 21

Location

United States

Related Subject Headings

  • Prenatal Exposure Delayed Effects
  • Prenatal Care
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Obstetric Labor, Premature
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Glucocorticoids
  • Follow-Up Studies