Time sequence and types of memory deficits after experimental status epilepticus.

Journal Article (Journal Article)

P35 rats subjected to kainate induced status epilepticus (SE) subsequently underwent four consecutive series of the Morris Water Maze. They demonstrated, compared with controls, an early (P46-49), and subsequent (P60-63) disturbance in acquisition, but not in long term retention, of spatial memory. They eventually achieved performance levels similar to those of controls (P74-77, P91-94). These data support the hypothesis that acquisition, but not long term retention, of spatial material is impaired in this model of temporal lobe epilepsy (TLE), probably due to the hippocampal injury that occurs after SE.

Full Text

Duke Authors

Cited Authors

  • Mikati, MA; Tarif, S; Lteif, L; Jawad, MA

Published Date

  • February 2001

Published In

Volume / Issue

  • 43 / 2

Start / End Page

  • 97 - 101

PubMed ID

  • 11164698

International Standard Serial Number (ISSN)

  • 0920-1211

Digital Object Identifier (DOI)

  • 10.1016/s0920-1211(00)00187-x


  • eng

Conference Location

  • Netherlands