Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats.

Published

Journal Article

PURPOSE: To investigate if energy precursor supplementation is neuroprotective in two neuroexcitotoxicity models; the kainate and the kainate followed by chronic phenobarbital models. METHODS: Rats in experiment 1 received 1% creatine or cyclocreatine chow from age (P) 21-65 days, underwent kainate induced status epilepticus on P35 and were compared, as adults, to kainate alone rats and to normal controls. Rats in experiment 2 received 1% creatine chow (P21-P85), underwent kainate status epilepticus on P35, received daily phenobarbital (or saline) injections (P36-P85) and were compared, as adults, to kainate, kainate-phenobarbital and to normal control rats that received regular chow. RESULTS: In experiment 1, the cyclocreatine-kainate group had increased emotionality and visuospatial learning deficits on the handling and watermaze tests as compared to all other groups. Creatine supplementation did not have any effects. In experiment 2, creatine supplementation did not prevent spontaneous recurrent seizures, aggressivity on the handling test or hippocampal histologic injury. CONCLUSION: Energy precursor supplementation in the doses used did not have neuroprotective effects in the kainate or kainate-phenobarbital models in pre-pubescent rats.

Full Text

Duke Authors

Cited Authors

  • Mikati, MA; Kurdit, RM; Rahmeh, AA; Farhat, F; Abu Rialy, S; Lteif, L; Francis, E; Geha, G; Maraashli, W

Published Date

  • December 2004

Published In

Volume / Issue

  • 18 / 12

Start / End Page

  • 1229 - 1241

PubMed ID

  • 15666567

Pubmed Central ID

  • 15666567

Electronic International Standard Serial Number (EISSN)

  • 1362-301X

International Standard Serial Number (ISSN)

  • 0269-9052

Digital Object Identifier (DOI)

  • 10.1080/02699050410001719880

Language

  • eng